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Multiplexed mRNA sensing and combinatorial-targeted drug delivery using DNA-gold nanoparticle dimers

Multiplexed mRNA sensing and combinatorial-targeted drug delivery using DNA-gold nanoparticle dimers
Multiplexed mRNA sensing and combinatorial-targeted drug delivery using DNA-gold nanoparticle dimers

The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.

copper-free click chemistry, gold nanoparticles, mRNA detection, nanoparticle dimmers, targeted drug delivery
1936-0851
3333-3340
Kyriazi, Maria Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Giust, Davide
fc70a34b-ee5e-4902-98b5-59cbb0e4ba7e
El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Kyriazi, Maria Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Giust, Davide
fc70a34b-ee5e-4902-98b5-59cbb0e4ba7e
El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Kyriazi, Maria Eleni, Giust, Davide, El-Sagheer, Afaf H., Lackie, Peter M., Muskens, Otto L., Brown, Tom and Kanaras, Antonios G. (2018) Multiplexed mRNA sensing and combinatorial-targeted drug delivery using DNA-gold nanoparticle dimers. ACS Nano, 12 (4), 3333-3340. (doi:10.1021/acsnano.7b08620).

Record type: Article

Abstract

The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.

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final_revised_kanaras_manuscript - Accepted Manuscript
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More information

Accepted/In Press date: 14 March 2018
e-pub ahead of print date: 20 March 2018
Published date: 24 April 2018
Keywords: copper-free click chemistry, gold nanoparticles, mRNA detection, nanoparticle dimmers, targeted drug delivery

Identifiers

Local EPrints ID: 421034
URI: https://eprints.soton.ac.uk/id/eprint/421034
ISSN: 1936-0851
PURE UUID: a4ba491c-3090-48d4-826b-c6e5fb589bbb
ORCID for Peter M. Lackie: ORCID iD orcid.org/0000-0001-7138-3764
ORCID for Otto L. Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 21 May 2018 16:30
Last modified: 15 Aug 2019 04:13

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