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Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy

Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy
Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy

Aim:

To compare microvascular reactivity assessed in the skin using laser Doppler fluximetry (LDF) in women with gestational diabetes mellitus (GDM) and gestational age-matched control during pregnancy.

Methods:

110 pregnant women at ~33 weeks gestation participated in the study. Skin microvascular reactivity was evaluated by LDF, at rest, during the response to brief arterial occlusion (post occlusive hyperaemic response) and during sympathetically mediated vasoconstrictor response to deep inspiratory breath hold.

Results:

No statistically significant differences were found in the microvascular variables studied (resting and maximum rate flux, post-ischaemic reactive hyperaemia and deep inspiratory breath holds) between +GDM and –GDM groups women. In women with GDM there was a negative correlation between resting flux and the response to the oral glucose tolerance test (OGTT), r = -0.282 (p = 0.037). There was also a negative correlation between the response to the OGTT and the sympathetically mediated constrictor response to inspiratory breath holds (r = -.298, p = .030) but not in women with GDM (r = .102, r = .468).

Conclusion:

Attenuated microvascular reactivity as an early marker of endothelial dysfunction is not present in women with GDM when assessed during pregnancy.
1758-5996
Pontes, Isabelle E.A.
17228ca6-fae1-434a-a126-3a86bad5ebb3
Afra, Karine F.
3c273257-bb76-437c-bb30-6f881cabba98
Silva Jr, Jose R.
39c02698-4603-4548-a57e-6534584d3be9
Borges, Paulo S.N.
eb3edbb5-ce34-4216-beab-912dd86202e6
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Alves, Joao G.B.
80126c96-d5c4-4fdc-9979-9f3b0d6426ab
Pontes, Isabelle E.A.
17228ca6-fae1-434a-a126-3a86bad5ebb3
Afra, Karine F.
3c273257-bb76-437c-bb30-6f881cabba98
Silva Jr, Jose R.
39c02698-4603-4548-a57e-6534584d3be9
Borges, Paulo S.N.
eb3edbb5-ce34-4216-beab-912dd86202e6
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Alves, Joao G.B.
80126c96-d5c4-4fdc-9979-9f3b0d6426ab

Pontes, Isabelle E.A., Afra, Karine F., Silva Jr, Jose R., Borges, Paulo S.N., Clough, Geraldine F. and Alves, Joao G.B. (2015) Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy. Diabetology & Metabolic Syndrome, 7 (27). (doi:10.1186/s13098-015-0017-4).

Record type: Article

Abstract


Aim:

To compare microvascular reactivity assessed in the skin using laser Doppler fluximetry (LDF) in women with gestational diabetes mellitus (GDM) and gestational age-matched control during pregnancy.

Methods:

110 pregnant women at ~33 weeks gestation participated in the study. Skin microvascular reactivity was evaluated by LDF, at rest, during the response to brief arterial occlusion (post occlusive hyperaemic response) and during sympathetically mediated vasoconstrictor response to deep inspiratory breath hold.

Results:

No statistically significant differences were found in the microvascular variables studied (resting and maximum rate flux, post-ischaemic reactive hyperaemia and deep inspiratory breath holds) between +GDM and –GDM groups women. In women with GDM there was a negative correlation between resting flux and the response to the oral glucose tolerance test (OGTT), r = -0.282 (p = 0.037). There was also a negative correlation between the response to the OGTT and the sympathetically mediated constrictor response to inspiratory breath holds (r = -.298, p = .030) but not in women with GDM (r = .102, r = .468).

Conclusion:

Attenuated microvascular reactivity as an early marker of endothelial dysfunction is not present in women with GDM when assessed during pregnancy.

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More information

Accepted/In Press date: 3 March 2015
e-pub ahead of print date: 28 March 2015

Identifiers

Local EPrints ID: 421042
URI: http://eprints.soton.ac.uk/id/eprint/421042
ISSN: 1758-5996
PURE UUID: 427e11bd-9673-4ad3-be44-f20116fe3cbd
ORCID for Geraldine F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 21 May 2018 16:30
Last modified: 26 Nov 2021 02:39

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Contributors

Author: Isabelle E.A. Pontes
Author: Karine F. Afra
Author: Jose R. Silva Jr
Author: Paulo S.N. Borges
Author: Joao G.B. Alves

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