Meningococcal infection and modified Neisseria lactamica
Meningococcal infection and modified Neisseria lactamica
The invention relates to a modified Neisseria lactamica, wherein the modified Neisseria lactamica is transformed with recombinant DNA encoding a heterologous protein; a method of prophylactic treatment for pathogenic infection of a subject comprising nasopharyngeal inoculation of a modified Neisseria lactamica; a method of reducing or preventing meningococcal colonisation of a subject; a method of modifying the microbiome of a subject; a wild-type Neisseria lactamica for use for the prophylactic treatment of meningococcal infection of a subject or reducing colonisation of a subject, wherein the prophylactic treatment comprises nasopharyngeal inoculation of the wild- type Neisseria lactamica; associated nucleic acid for mutagenesis of Neisseria lactamica; methods of mutagenesis; outer membrane vesicle (OMV) vaccines; and associated compositions and methods thereof.
WO2017103593A1
15 December 2015
Laver, Jay
b2996398-2ccf-40f0-92b8-f338f3de796b
Read, Robert
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Laver, Jay and Read, Robert
(Inventors)
(2015)
Meningococcal infection and modified Neisseria lactamica.
WO2017103593A1.
Abstract
The invention relates to a modified Neisseria lactamica, wherein the modified Neisseria lactamica is transformed with recombinant DNA encoding a heterologous protein; a method of prophylactic treatment for pathogenic infection of a subject comprising nasopharyngeal inoculation of a modified Neisseria lactamica; a method of reducing or preventing meningococcal colonisation of a subject; a method of modifying the microbiome of a subject; a wild-type Neisseria lactamica for use for the prophylactic treatment of meningococcal infection of a subject or reducing colonisation of a subject, wherein the prophylactic treatment comprises nasopharyngeal inoculation of the wild- type Neisseria lactamica; associated nucleic acid for mutagenesis of Neisseria lactamica; methods of mutagenesis; outer membrane vesicle (OMV) vaccines; and associated compositions and methods thereof.
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WO2017103593A1
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Submitted date: 15 December 2015
Published date: 15 December 2015
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Local EPrints ID: 421174
URI: http://eprints.soton.ac.uk/id/eprint/421174
PURE UUID: a92929b1-95f2-4168-b325-cc32786cfd1c
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Date deposited: 24 May 2018 16:30
Last modified: 06 Jun 2024 01:51
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