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Genetics and genetic testing for age-related macular degeneration review-article

Genetics and genetic testing for age-related macular degeneration review-article
Genetics and genetic testing for age-related macular degeneration review-article

Considerable advances have been made in our understanding of age-related macular degeneration (AMD) genetics over the past decade. The genetic associations discovered to date are estimated to account for approximately half of AMD heritability, and functional studies of these variants have revealed new insights into disease pathogenesis, leading to the development of potential novel therapies. There is furthermore growing interest in genetic testing for predicting an individual's risk of AMD and offering personalised preventive or therapeutic treatments. We review the progress made so far in AMD genetics and discuss the possible applications for genetic testing.

0950-222X
849-857
Warwick, A.
eab9cc60-6a67-48a7-9210-580756aa17a7
Lotery, A.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Warwick, A.
eab9cc60-6a67-48a7-9210-580756aa17a7
Lotery, A.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Warwick, A. and Lotery, A. (2018) Genetics and genetic testing for age-related macular degeneration review-article. Eye (Basingstoke), 32 (5), 849-857. (doi:10.1038/eye.2017.245).

Record type: Review

Abstract

Considerable advances have been made in our understanding of age-related macular degeneration (AMD) genetics over the past decade. The genetic associations discovered to date are estimated to account for approximately half of AMD heritability, and functional studies of these variants have revealed new insights into disease pathogenesis, leading to the development of potential novel therapies. There is furthermore growing interest in genetic testing for predicting an individual's risk of AMD and offering personalised preventive or therapeutic treatments. We review the progress made so far in AMD genetics and discuss the possible applications for genetic testing.

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021017 AMD genetics review EYE resubmission - Accepted Manuscript
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More information

Accepted/In Press date: 9 October 2017
e-pub ahead of print date: 10 November 2017
Published date: 1 May 2018

Identifiers

Local EPrints ID: 421244
URI: http://eprints.soton.ac.uk/id/eprint/421244
ISSN: 0950-222X
PURE UUID: 3d586535-f07f-49cc-b994-354d03cb75e9
ORCID for A. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 29 May 2018 16:30
Last modified: 07 Oct 2020 01:48

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