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IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects

IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects
IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects

Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level <50 nmol/L), aged 40.4 ± 11.4 years, were given vitamin D supplements (50,000 IU/mL every week) for the first 2 months, then twice a month for 2 months, followed by daily 1000 IU in the last 2 months. Fasting blood samples were taken at baseline and 6 months after the final dose of vitamin D. Serum 25(OH)D, IGF-1 and IGF-2, and IGFBPs 2-5 were measured. Vitamin D response was computed for all subjects as the difference in levels of serum 25(OH)D concentration at the end of 6 months compared to baseline. After intervention, serum 25(OH)D concentration significantly increased from 35.6 nmol/L (26.6-43.5) to 61.8 nmol/L (54.8-73.3) in responder subjects (P < .01) and from 35.1 nmol/L (21.2-58.2) to 38.3 nmol/L (25.5-48.3) in nonresponders (P = .13). Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes. IGF1 and IGF-1/IGFBP-3 ratio significantly increased in all subjects after 6 months (P = .01). Changes in 25(OH)D was significantly associated with changes in IGFBP-2 and IGF-1/IGFBP-3 ratio in responders only. This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population.

1357-3039
e0702
Al-Daghri, Nasser M.
0bf1023c-a104-4f74-8b06-87780dfbd8b4
Yakout, Sobhy M.
43604260-922d-431e-8230-4175e07e0da3
Wani, Kaiser
44ab416a-4405-4b5d-8061-5defb73af5df
Khattak, Malak Nawaz Khan
ce6e6491-56b7-4c7f-b9ff-d2f771bf3c60
Garbis, Spiro D.
7067fd19-50c9-4d42-9611-f370289470bd
Chrousos, George P.
28beffd9-c486-4cf4-a012-06745681d811
Al-Attas, Omar S.
ae24b43e-3979-4d3f-ae7b-a9a77a113294
Alokail, Majed S.
9adf2d61-d9f7-4095-bc36-701f0680646a
Al-Daghri, Nasser M.
0bf1023c-a104-4f74-8b06-87780dfbd8b4
Yakout, Sobhy M.
43604260-922d-431e-8230-4175e07e0da3
Wani, Kaiser
44ab416a-4405-4b5d-8061-5defb73af5df
Khattak, Malak Nawaz Khan
ce6e6491-56b7-4c7f-b9ff-d2f771bf3c60
Garbis, Spiro D.
7067fd19-50c9-4d42-9611-f370289470bd
Chrousos, George P.
28beffd9-c486-4cf4-a012-06745681d811
Al-Attas, Omar S.
ae24b43e-3979-4d3f-ae7b-a9a77a113294
Alokail, Majed S.
9adf2d61-d9f7-4095-bc36-701f0680646a

Al-Daghri, Nasser M., Yakout, Sobhy M., Wani, Kaiser, Khattak, Malak Nawaz Khan, Garbis, Spiro D., Chrousos, George P., Al-Attas, Omar S. and Alokail, Majed S. (2018) IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects. Medicine, 97 (19), e0702. (doi:10.1097/MD.0000000000010702).

Record type: Article

Abstract

Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level <50 nmol/L), aged 40.4 ± 11.4 years, were given vitamin D supplements (50,000 IU/mL every week) for the first 2 months, then twice a month for 2 months, followed by daily 1000 IU in the last 2 months. Fasting blood samples were taken at baseline and 6 months after the final dose of vitamin D. Serum 25(OH)D, IGF-1 and IGF-2, and IGFBPs 2-5 were measured. Vitamin D response was computed for all subjects as the difference in levels of serum 25(OH)D concentration at the end of 6 months compared to baseline. After intervention, serum 25(OH)D concentration significantly increased from 35.6 nmol/L (26.6-43.5) to 61.8 nmol/L (54.8-73.3) in responder subjects (P < .01) and from 35.1 nmol/L (21.2-58.2) to 38.3 nmol/L (25.5-48.3) in nonresponders (P = .13). Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes. IGF1 and IGF-1/IGFBP-3 ratio significantly increased in all subjects after 6 months (P = .01). Changes in 25(OH)D was significantly associated with changes in IGFBP-2 and IGF-1/IGFBP-3 ratio in responders only. This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population.

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Accepted/In Press date: 20 April 2018
e-pub ahead of print date: 1 May 2018
Published date: 1 May 2018

Identifiers

Local EPrints ID: 421250
URI: https://eprints.soton.ac.uk/id/eprint/421250
ISSN: 1357-3039
PURE UUID: db0d720f-1beb-4b87-a0d2-51a576d7ef8c

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Date deposited: 29 May 2018 16:30
Last modified: 13 Mar 2019 18:26

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