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The genomic and epigenomic landscape of chronic lymphocytic leukemia

The genomic and epigenomic landscape of chronic lymphocytic leukemia
The genomic and epigenomic landscape of chronic lymphocytic leukemia

Due to its prevalence, protracted natural history, and accessibility to suitable material, chronic lymphocytic leukemia (CLL) remains an attractive model to understand the processes of cancer progression and evolution. Genome-wide genomic and epigenetic approaches have delivered an unparalleled view of the architecture of the CLL (epi)genome, so that we now possess an extensive catalogue of the copy number, mutational and epigenetic landscape of the disease, a precise description of clonal evolution, several key molecular mechanisms that drive genomic instability and therapeutic resistance, and an in-depth list of gene loci that contribute to disease predisposition. This work has provided novel insights into the prognostic importance of copy number changes, and identified novel prognostically relevant gene mutations that function within biological pathways that are attractive treatment targets and epigenetic alterations that point to the disease’s cell of origin. Herein, an overview of recent (epi)genomic landmark discoveries is discussed, with associated clinical and biological implications.

CLL, Clonal evolution, Copy number alterations, Cytogenetic abnormalities, Disease transformation, Epigenetics, Gene mutations, Genetic predisposition, Genomic complexity, Genomic lesions in clinical practice, TP53
99-116
Springer International Publishing AG
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Walewska, Renata
326c1001-fcdb-452a-aa53-2c82a1ca39a5
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Wiernik, P.
Dutcher, J.
Gertz, M.
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Walewska, Renata
326c1001-fcdb-452a-aa53-2c82a1ca39a5
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Wiernik, P.
Dutcher, J.
Gertz, M.

Strefford, Jonathan C., Walewska, Renata and Oscier, David G. (2018) The genomic and epigenomic landscape of chronic lymphocytic leukemia. In, Wiernik, P., Dutcher, J. and Gertz, M. (eds.) Neoplastic Diseases of the Blood. Cham. Springer International Publishing AG, pp. 99-116. (doi:10.1007/978-3-319-64263-5_8).

Record type: Book Section

Abstract

Due to its prevalence, protracted natural history, and accessibility to suitable material, chronic lymphocytic leukemia (CLL) remains an attractive model to understand the processes of cancer progression and evolution. Genome-wide genomic and epigenetic approaches have delivered an unparalleled view of the architecture of the CLL (epi)genome, so that we now possess an extensive catalogue of the copy number, mutational and epigenetic landscape of the disease, a precise description of clonal evolution, several key molecular mechanisms that drive genomic instability and therapeutic resistance, and an in-depth list of gene loci that contribute to disease predisposition. This work has provided novel insights into the prognostic importance of copy number changes, and identified novel prognostically relevant gene mutations that function within biological pathways that are attractive treatment targets and epigenetic alterations that point to the disease’s cell of origin. Herein, an overview of recent (epi)genomic landmark discoveries is discussed, with associated clinical and biological implications.

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More information

e-pub ahead of print date: 9 September 2017
Published date: 1 January 2018
Keywords: CLL, Clonal evolution, Copy number alterations, Cytogenetic abnormalities, Disease transformation, Epigenetics, Gene mutations, Genetic predisposition, Genomic complexity, Genomic lesions in clinical practice, TP53

Identifiers

Local EPrints ID: 421268
URI: https://eprints.soton.ac.uk/id/eprint/421268
PURE UUID: 20dd595a-516f-4c29-8a3b-257dd7984bb8
ORCID for Jonathan C. Strefford: ORCID iD orcid.org/0000-0002-0972-2881

Catalogue record

Date deposited: 30 May 2018 16:30
Last modified: 20 Jul 2019 00:58

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Contributors

Author: Renata Walewska
Author: David G. Oscier
Editor: P. Wiernik
Editor: J. Dutcher
Editor: M. Gertz

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