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Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD

Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD
Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD
Background: small airways disease (SAD) is considered pivotal in the pathology of COPD. There are numerous publications describing physiological and Computed Tomography (CT) imaging markers to detect SAD. However, there is no agreed gold standard and limited understanding of the clinical associations of these measures to disease outcomes.

Methods: we conducted a systematic review using Embase, Medline and Pubmed to explore the relationship between physiological and CT SAD measures in COPD (GOLD Stages 1–4). Furthermore, evidence linking these physiological measures with defined clinical outcomes such as health status, functional assessment and exacerbation frequency were summarised.

Results: the search yielded 1160 abstracts of which 19 met the search criteria. Six studies examined physiological and CT measures while 13 publications identified physiological measures and clinical outcomes. Strong correlations were seen between CT and physiological measures of SAD. Varying associations between physiological measures and defined clinical outcomes were noted.

Conclusions: physiological and CT measures of SAD correlate and infer similar information. Physiological measures of SAD may offer valuable insight into clinical expression of the disease. A consensus on the standardisation and recommendation of tests to measure SAD is needed in order to better understand any clinical benefits of targeted drug therapy to the small airways.
0954-6111
117-125
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Wilkinson, Tom
e6e24c51-d712-4202-8d87-e40f0e116b56
Jack, Sandy
9dd4654b-cebb-463a-9870-c5a36ce74841
Ostridge, Kristoffer
d2271bae-b078-4390-8919-8f8c0e20542c
Thompson, Bruce
0b7b7407-57cb-4502-9e32-152a2f3b0c2f
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Wilkinson, Tom
e6e24c51-d712-4202-8d87-e40f0e116b56
Jack, Sandy
9dd4654b-cebb-463a-9870-c5a36ce74841
Ostridge, Kristoffer
d2271bae-b078-4390-8919-8f8c0e20542c
Thompson, Bruce
0b7b7407-57cb-4502-9e32-152a2f3b0c2f
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06

Gove, Kerry, Wilkinson, Tom, Jack, Sandy, Ostridge, Kristoffer, Thompson, Bruce and Conway, Joy (2018) Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD. Respiratory Medicine, 139, 117-125. (doi:10.1016/j.rmed.2018.05.005).

Record type: Review

Abstract

Background: small airways disease (SAD) is considered pivotal in the pathology of COPD. There are numerous publications describing physiological and Computed Tomography (CT) imaging markers to detect SAD. However, there is no agreed gold standard and limited understanding of the clinical associations of these measures to disease outcomes.

Methods: we conducted a systematic review using Embase, Medline and Pubmed to explore the relationship between physiological and CT SAD measures in COPD (GOLD Stages 1–4). Furthermore, evidence linking these physiological measures with defined clinical outcomes such as health status, functional assessment and exacerbation frequency were summarised.

Results: the search yielded 1160 abstracts of which 19 met the search criteria. Six studies examined physiological and CT measures while 13 publications identified physiological measures and clinical outcomes. Strong correlations were seen between CT and physiological measures of SAD. Varying associations between physiological measures and defined clinical outcomes were noted.

Conclusions: physiological and CT measures of SAD correlate and infer similar information. Physiological measures of SAD may offer valuable insight into clinical expression of the disease. A consensus on the standardisation and recommendation of tests to measure SAD is needed in order to better understand any clinical benefits of targeted drug therapy to the small airways.

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Accepted/In Press date: 6 May 2018
e-pub ahead of print date: 9 May 2018
Published date: June 2018

Identifiers

Local EPrints ID: 421400
URI: http://eprints.soton.ac.uk/id/eprint/421400
ISSN: 0954-6111
PURE UUID: 0eca49a1-d669-4168-b894-8e2084dde2d7
ORCID for Joy Conway: ORCID iD orcid.org/0000-0001-6464-1526

Catalogue record

Date deposited: 08 Jun 2018 16:30
Last modified: 26 Nov 2021 06:26

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Contributors

Author: Kerry Gove
Author: Tom Wilkinson
Author: Sandy Jack
Author: Kristoffer Ostridge
Author: Bruce Thompson
Author: Joy Conway ORCID iD

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