Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells
Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells
Joint replacements have proved a medical success providing symptomatic relief and return to mobility in many patients with arthritis. However, multiple revision surgeries due to joint failure can result in complex revision scenarios with significant bone tissue loss, in an elderly population, which poses a significant clinical challenge. Computer-aided design-computer-assisted manufacturing (CAD-CAM) prototyped bespoke implants are currently being used as an alternative and innovative approach for joint restoration in salvage cases, while the incorporation of autologous skeletal stem cells to optimize regenerative capacity can enhance implant osseointegration. We present a case series of 11 patients with severe disability and significant bone loss due to failed joint replacements. The choice of CAD-CAM prototyped joint implants enhanced with autologous skeletal stem cells resulted in significant patient-reported clinical and radiological improvements.
joint replacement, orthopedics, regenerative medicine, revision surgery, skeletal stem cells
283-294
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
McEwan, Josephine K.
76f157c4-6c4e-4c3e-98bd-9997de8f2594
Oreffo, Richard Oc
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Dunlop, Doug G.
531e164e-1d31-4e37-bed3-08b1587442b7
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
McEwan, Josephine K.
76f157c4-6c4e-4c3e-98bd-9997de8f2594
Oreffo, Richard Oc
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dunlop, Doug G.
531e164e-1d31-4e37-bed3-08b1587442b7
Goriainov, Vitali, McEwan, Josephine K., Oreffo, Richard Oc and Dunlop, Doug G.
(2018)
Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells.
Regenerative Medicine, 13 (3), .
(doi:10.2217/rme-2017-0127).
Abstract
Joint replacements have proved a medical success providing symptomatic relief and return to mobility in many patients with arthritis. However, multiple revision surgeries due to joint failure can result in complex revision scenarios with significant bone tissue loss, in an elderly population, which poses a significant clinical challenge. Computer-aided design-computer-assisted manufacturing (CAD-CAM) prototyped bespoke implants are currently being used as an alternative and innovative approach for joint restoration in salvage cases, while the incorporation of autologous skeletal stem cells to optimize regenerative capacity can enhance implant osseointegration. We present a case series of 11 patients with severe disability and significant bone loss due to failed joint replacements. The choice of CAD-CAM prototyped joint implants enhanced with autologous skeletal stem cells resulted in significant patient-reported clinical and radiological improvements.
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Accepted/In Press date: 6 February 2018
e-pub ahead of print date: 1 May 2018
Keywords:
joint replacement, orthopedics, regenerative medicine, revision surgery, skeletal stem cells
Identifiers
Local EPrints ID: 421452
URI: http://eprints.soton.ac.uk/id/eprint/421452
ISSN: 1746-0751
PURE UUID: 0420e270-8799-4a35-8b73-a76db03895c3
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Date deposited: 12 Jun 2018 16:30
Last modified: 18 Mar 2024 02:51
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Contributors
Author:
Vitali Goriainov
Author:
Josephine K. McEwan
Author:
Doug G. Dunlop
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