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The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes

The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes
The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes

PURPOSE: The present study investigated different doses of ultraviolet-A (UV-A) light on plasma nitric oxide metabolites and cardiorespiratory variables.

METHODS: Ten healthy male participants completed three experimental conditions, 7 days apart. Participants were exposed to no light (CON); 10 J cm2 (15 min) of UV-A light (UVA10) and 20 J cm2 (30 min) of UV-A light (UVA20) in a randomized order. Plasma nitrite [NO2-] and nitrate [NO3-] concentrations, blood pressure (BP), and heart rate (HR) were recorded before, immediately after exposure and 30 min post-exposure. Whole body oxygen utilization ([Formula: see text]), resting metabolic rate (RMR) and skin temperature were recorded continuously.

RESULTS: None of the measured parameters changed significantly during CON (all P > 0.05). [Formula: see text] and RMR were significantly reduced immediately after UVA10 (P < 0.05) despite no change in plasma [NO2-] (P > 0.05). Immediately after exposure to UVA20, plasma [NO2-] was higher (P = 0.014) and [Formula: see text] and RMR tended to be lower compared to baseline (P = 0.06). There were no differences in [NO2-] or [Formula: see text] at the 30 min time point in any condition. UV-A exposure did not alter systolic BP, diastolic BP or MAP (all P > 0.05). UV-A light did not alter plasma [NO3-] at any time point (all P > 0.05).

CONCLUSIONS: This study demonstrates that a UV-A dose of 20 J cm2 is necessary to increase plasma [NO2-] although a smaller dose is capable of reducing [Formula: see text] and RMR at rest. Exposure to UV-A did not significantly reduce BP in this cohort of healthy adults. These data suggest that exposure to sunlight has a meaningful acute impact on metabolic function.

Journal Article
1439-6319
1043-1052
Monaghan, Chris
58f45991-cd8e-49a6-af16-158cc0e27a8d
McIlvenna, Luke C.
14e111c7-3882-41e1-b104-7c2ebb6bbe85
Liddle, Luke
fc412297-ec88-4d99-a3c2-9570b5e682e9
Burleigh, Mia
cd675872-734e-4267-b528-e9e77da4d75a
Weller, Richard B.
6760c78a-63ae-484a-affa-b435f146e5a3
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Muggeridge, David J.
336fd016-225f-485b-9122-dea4455ab7f3
Easton, Chris
76f6cbdd-284c-477f-8d6a-5d11aaced94c
Monaghan, Chris
58f45991-cd8e-49a6-af16-158cc0e27a8d
McIlvenna, Luke C.
14e111c7-3882-41e1-b104-7c2ebb6bbe85
Liddle, Luke
fc412297-ec88-4d99-a3c2-9570b5e682e9
Burleigh, Mia
cd675872-734e-4267-b528-e9e77da4d75a
Weller, Richard B.
6760c78a-63ae-484a-affa-b435f146e5a3
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Muggeridge, David J.
336fd016-225f-485b-9122-dea4455ab7f3
Easton, Chris
76f6cbdd-284c-477f-8d6a-5d11aaced94c

Monaghan, Chris, McIlvenna, Luke C., Liddle, Luke, Burleigh, Mia, Weller, Richard B., Fernandez, Bernadette O., Feelisch, Martin, Muggeridge, David J. and Easton, Chris (2018) The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes. European Journal of Applied Physiology, 118 (5), 1043-1052. (doi:10.1007/s00421-018-3835-x).

Record type: Article

Abstract

PURPOSE: The present study investigated different doses of ultraviolet-A (UV-A) light on plasma nitric oxide metabolites and cardiorespiratory variables.

METHODS: Ten healthy male participants completed three experimental conditions, 7 days apart. Participants were exposed to no light (CON); 10 J cm2 (15 min) of UV-A light (UVA10) and 20 J cm2 (30 min) of UV-A light (UVA20) in a randomized order. Plasma nitrite [NO2-] and nitrate [NO3-] concentrations, blood pressure (BP), and heart rate (HR) were recorded before, immediately after exposure and 30 min post-exposure. Whole body oxygen utilization ([Formula: see text]), resting metabolic rate (RMR) and skin temperature were recorded continuously.

RESULTS: None of the measured parameters changed significantly during CON (all P > 0.05). [Formula: see text] and RMR were significantly reduced immediately after UVA10 (P < 0.05) despite no change in plasma [NO2-] (P > 0.05). Immediately after exposure to UVA20, plasma [NO2-] was higher (P = 0.014) and [Formula: see text] and RMR tended to be lower compared to baseline (P = 0.06). There were no differences in [NO2-] or [Formula: see text] at the 30 min time point in any condition. UV-A exposure did not alter systolic BP, diastolic BP or MAP (all P > 0.05). UV-A light did not alter plasma [NO3-] at any time point (all P > 0.05).

CONCLUSIONS: This study demonstrates that a UV-A dose of 20 J cm2 is necessary to increase plasma [NO2-] although a smaller dose is capable of reducing [Formula: see text] and RMR at rest. Exposure to UV-A did not significantly reduce BP in this cohort of healthy adults. These data suggest that exposure to sunlight has a meaningful acute impact on metabolic function.

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More information

Accepted/In Press date: 1 March 2018
e-pub ahead of print date: 7 March 2018
Published date: May 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 421453
URI: http://eprints.soton.ac.uk/id/eprint/421453
ISSN: 1439-6319
PURE UUID: fb60889e-c714-4008-9bab-6e49a4eaf019
ORCID for Bernadette O. Fernandez: ORCID iD orcid.org/0000-0001-6337-0381
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 12 Jun 2018 16:30
Last modified: 26 Nov 2021 03:00

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Contributors

Author: Chris Monaghan
Author: Luke C. McIlvenna
Author: Luke Liddle
Author: Mia Burleigh
Author: Richard B. Weller
Author: Bernadette O. Fernandez ORCID iD
Author: Martin Feelisch ORCID iD
Author: David J. Muggeridge
Author: Chris Easton

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