The University of Southampton
University of Southampton Institutional Repository

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies. Small-group allocations were performed a priori to ensure that each group included different stakeholders from a variety of geographical regions. Anonymous whole-group voting was carried out using handheld electronic voting pads according to predefined consensus rules. It was agreed by consensus that the long-term control domain should include signs, symptoms, quality of life and a patient global instrument. The group agreed that itch intensity should be measured when assessing long-term control of eczema in addition to the frequency of itch captured by the symptoms domain. There was no recommendation of an instrument for the core outcome domain of quality of life in children, but existing instruments were assessed for face validity and feasibility, and future work that will facilitate the recommendation of an instrument was agreed upon.

0007-0963
e332-e341
Chalmers, J.R.
f37428ae-6bbf-44d6-94ca-72508ce3c99f
Thomas, K.S.
3eb8b4f5-2076-4edc-a7f5-30787773e1bf
Apfelbacher, C.
899a7e66-f002-47d6-9a63-01399fc18c43
Williams, H.C.
41a47f08-d65d-4c83-ba87-139a31125483
Prinsen, C.A.
014fd966-f97f-4485-9677-26ef19d8dcdb
Spuls, P.I.
64e79fa0-52d6-46c1-b28f-fbf31724c52d
Simpson, E.
127514a1-9431-48d2-b3dc-ff871a5e4155
Gerbens, L.A.A.
e6800106-6232-44f1-ab9d-b1e7e6ad66d9
Boers, M.
1e4a9620-354d-4b5a-a978-4de78fd3f6c3
Barbarot, S.
21733708-e6a2-4b5d-9559-eac8e437c18e
Stalder, J.F.
628af7fd-948f-4fad-8fea-abe963b40460
Abuabara, K.
10a2192f-d7fb-4ef8-90d4-b58cc0aa9c7c
Aoki, V.
cc60023d-d343-4c9d-9dab-ff8a8806ada8
Ardeleanu, M.
ee060a44-0227-47bb-9a8e-adfe4a8cc477
Armstrong, J.
a818b71d-a930-4667-aea6-0ca2d3ea984f
Bang, B.
95fe84f4-72aa-44b1-82d2-a54256f72493
Berents, T.L.
4d5592ee-c8f5-4034-b765-0391bbef5eb4
Burton, T.
1d9bc90f-b429-4a67-8318-c0042363d3df
Butler, L.
ac3431ef-a318-45c4-8083-c6c88a91449d
Chubachi, T.
633caf0e-cda3-4a3c-bb02-b086aec49a58
Cresswell-Melville, A.
63e4bf7e-4780-4c8b-8305-d4cab8355894
DeLozier, A.
8407131a-7c86-4797-8cc0-f82b5af0250a
Eckert, L.
b39d6f77-12a4-4e28-8a63-69bc94a992fa
Eichenfield, L.
9f1aa9bd-88a8-41ae-8d0b-569482147b30
Flohr, C.
2cd7a518-1a24-4fc7-b099-2a032fdf2068
Futamura, M.
e60630d5-1817-4708-bdcc-5f8e1545dcec
Gadkari, A.
4b4aa735-df51-4d49-b064-c04e3b214f29
Gjerde, E.S.
91997fe4-6242-44ae-af6b-fbd5e22f7868
van Halewijn, K.F.
3269a538-e2b0-41e1-88c9-f43d30f6d958
Hawkes, C.
031a17ac-0931-4ff9-93cc-df8cb58e14f7
Howells, L.
e8a7382e-179a-446e-8efa-c92cf3226fb5
Howie, L.
13a048d0-dc7b-44e2-8683-1b7f100ff8dc
Humphreys, R.
2c4f9511-1da6-4192-83f1-d053978cd898
Ishii, H.A.
9f815fe9-a09e-4ab9-a74b-b965fe85ed83
Kataoka, Y.
0d8cb2b8-0dea-45e5-9b2f-e813bfc1a41c
Katayama, I.
5fc3e7dc-85c6-4341-8504-328654a176a9
Kouwenhoven, W.
1dc6debf-8c13-4a7f-a81a-05686ff2f8e2
Langan, S.M.
34b0a654-2b99-424a-893a-f4b5eee197ee
Leshem, Y.A.
2b93efc1-acd0-4275-835c-7e42eb90a4c7
Merhand, S.
72db0d60-48bd-482b-8893-5eb4437c9c64
Mina-Osorio, P.
58960221-b4f1-42cc-93e2-ef77d39191e3
Murota, H.
0bdbddc6-c373-42fb-9c35-911f7979e477
Nakahara, T.
f19d5235-0589-4f90-bca0-59dd486a5679
Nunes, F.P.
5fd663de-6744-4ae8-911b-66971c1c356b
Nygaard, U.
87d48606-74f6-448c-b2c7-f7c5d430277e
Nygårdas, M.
51f41380-6b52-4f88-a72f-60fde87b3f16
Ohya, Y.
4ad7d24a-4ae4-4320-a658-56d645b8365d
Ono, E.
fee0bd48-90f4-4ec2-b20b-6e2ecf32b99e
Rehbinder, E.
e0099ce8-2827-4c91-86cf-65a00c46be40
Rogers, N.K.
a322aec5-2dd3-4b01-8e75-a2cce0cd8619
Romeijn, G.L.E.
f6796fd1-30fc-4210-8db5-604a263bea0e
Schuttelaar, M.L.A.
1cc04a86-1615-431c-bb4a-c6492678824c
Sears, A.V.
5c79e243-bafd-4d62-8441-926dd7bbbc8e
Simpson, M.A.
7ab06621-5f17-4ada-9e91-bf201977cf84
Singh, J.A.
cc8a4062-8d9f-46d3-af25-03769cf2e20d
Srour, J.
f2a74fb5-f232-4528-9891-dd8b81a8fe07
Stuart, B.
626862fc-892b-4f6d-9cbb-7a8d7172b209
Svensson,
8b794d07-ccf0-4469-9de3-d3e601a61a24
Talmo, G.
9e2db431-0231-4066-a61f-1467dff0dcc2
Talmo, H.
aca91a5a-6e8f-4f48-8fd6-315a56623296
Teixeira, H.D.
639a7d6c-b5f4-4478-b7ad-74359b75b1ae
Thyssen, J.P.
00c73b00-e707-42ec-9a80-5f3d003dea32
Todd, G.
f3d54068-e11d-4d3a-945a-5faa4bf435b2
Torchet, F.
67ac764a-6ad9-40b9-91d1-4dbba04630e5
Volke, A.
d0d077ab-0afd-444b-b14e-56c30a078d64
von Kobyletzki, L.
8fbbf78b-e2e2-4ad7-ad3f-29d313521873
Weisshaar, E.
e9fe5071-c945-4a80-8c96-8ee37b1c42db
Wollenberg, A.
b8732e3a-228f-4f60-84fa-e69bbb117c30
Zaniboni, M.
9bea8449-f073-4409-9169-50d1eaba6f8c
Chalmers, J.R.
f37428ae-6bbf-44d6-94ca-72508ce3c99f
Thomas, K.S.
3eb8b4f5-2076-4edc-a7f5-30787773e1bf
Apfelbacher, C.
899a7e66-f002-47d6-9a63-01399fc18c43
Williams, H.C.
41a47f08-d65d-4c83-ba87-139a31125483
Prinsen, C.A.
014fd966-f97f-4485-9677-26ef19d8dcdb
Spuls, P.I.
64e79fa0-52d6-46c1-b28f-fbf31724c52d
Simpson, E.
127514a1-9431-48d2-b3dc-ff871a5e4155
Gerbens, L.A.A.
e6800106-6232-44f1-ab9d-b1e7e6ad66d9
Boers, M.
1e4a9620-354d-4b5a-a978-4de78fd3f6c3
Barbarot, S.
21733708-e6a2-4b5d-9559-eac8e437c18e
Stalder, J.F.
628af7fd-948f-4fad-8fea-abe963b40460
Abuabara, K.
10a2192f-d7fb-4ef8-90d4-b58cc0aa9c7c
Aoki, V.
cc60023d-d343-4c9d-9dab-ff8a8806ada8
Ardeleanu, M.
ee060a44-0227-47bb-9a8e-adfe4a8cc477
Armstrong, J.
a818b71d-a930-4667-aea6-0ca2d3ea984f
Bang, B.
95fe84f4-72aa-44b1-82d2-a54256f72493
Berents, T.L.
4d5592ee-c8f5-4034-b765-0391bbef5eb4
Burton, T.
1d9bc90f-b429-4a67-8318-c0042363d3df
Butler, L.
ac3431ef-a318-45c4-8083-c6c88a91449d
Chubachi, T.
633caf0e-cda3-4a3c-bb02-b086aec49a58
Cresswell-Melville, A.
63e4bf7e-4780-4c8b-8305-d4cab8355894
DeLozier, A.
8407131a-7c86-4797-8cc0-f82b5af0250a
Eckert, L.
b39d6f77-12a4-4e28-8a63-69bc94a992fa
Eichenfield, L.
9f1aa9bd-88a8-41ae-8d0b-569482147b30
Flohr, C.
2cd7a518-1a24-4fc7-b099-2a032fdf2068
Futamura, M.
e60630d5-1817-4708-bdcc-5f8e1545dcec
Gadkari, A.
4b4aa735-df51-4d49-b064-c04e3b214f29
Gjerde, E.S.
91997fe4-6242-44ae-af6b-fbd5e22f7868
van Halewijn, K.F.
3269a538-e2b0-41e1-88c9-f43d30f6d958
Hawkes, C.
031a17ac-0931-4ff9-93cc-df8cb58e14f7
Howells, L.
e8a7382e-179a-446e-8efa-c92cf3226fb5
Howie, L.
13a048d0-dc7b-44e2-8683-1b7f100ff8dc
Humphreys, R.
2c4f9511-1da6-4192-83f1-d053978cd898
Ishii, H.A.
9f815fe9-a09e-4ab9-a74b-b965fe85ed83
Kataoka, Y.
0d8cb2b8-0dea-45e5-9b2f-e813bfc1a41c
Katayama, I.
5fc3e7dc-85c6-4341-8504-328654a176a9
Kouwenhoven, W.
1dc6debf-8c13-4a7f-a81a-05686ff2f8e2
Langan, S.M.
34b0a654-2b99-424a-893a-f4b5eee197ee
Leshem, Y.A.
2b93efc1-acd0-4275-835c-7e42eb90a4c7
Merhand, S.
72db0d60-48bd-482b-8893-5eb4437c9c64
Mina-Osorio, P.
58960221-b4f1-42cc-93e2-ef77d39191e3
Murota, H.
0bdbddc6-c373-42fb-9c35-911f7979e477
Nakahara, T.
f19d5235-0589-4f90-bca0-59dd486a5679
Nunes, F.P.
5fd663de-6744-4ae8-911b-66971c1c356b
Nygaard, U.
87d48606-74f6-448c-b2c7-f7c5d430277e
Nygårdas, M.
51f41380-6b52-4f88-a72f-60fde87b3f16
Ohya, Y.
4ad7d24a-4ae4-4320-a658-56d645b8365d
Ono, E.
fee0bd48-90f4-4ec2-b20b-6e2ecf32b99e
Rehbinder, E.
e0099ce8-2827-4c91-86cf-65a00c46be40
Rogers, N.K.
a322aec5-2dd3-4b01-8e75-a2cce0cd8619
Romeijn, G.L.E.
f6796fd1-30fc-4210-8db5-604a263bea0e
Schuttelaar, M.L.A.
1cc04a86-1615-431c-bb4a-c6492678824c
Sears, A.V.
5c79e243-bafd-4d62-8441-926dd7bbbc8e
Simpson, M.A.
7ab06621-5f17-4ada-9e91-bf201977cf84
Singh, J.A.
cc8a4062-8d9f-46d3-af25-03769cf2e20d
Srour, J.
f2a74fb5-f232-4528-9891-dd8b81a8fe07
Stuart, B.
626862fc-892b-4f6d-9cbb-7a8d7172b209
Svensson,
8b794d07-ccf0-4469-9de3-d3e601a61a24
Talmo, G.
9e2db431-0231-4066-a61f-1467dff0dcc2
Talmo, H.
aca91a5a-6e8f-4f48-8fd6-315a56623296
Teixeira, H.D.
639a7d6c-b5f4-4478-b7ad-74359b75b1ae
Thyssen, J.P.
00c73b00-e707-42ec-9a80-5f3d003dea32
Todd, G.
f3d54068-e11d-4d3a-945a-5faa4bf435b2
Torchet, F.
67ac764a-6ad9-40b9-91d1-4dbba04630e5
Volke, A.
d0d077ab-0afd-444b-b14e-56c30a078d64
von Kobyletzki, L.
8fbbf78b-e2e2-4ad7-ad3f-29d313521873
Weisshaar, E.
e9fe5071-c945-4a80-8c96-8ee37b1c42db
Wollenberg, A.
b8732e3a-228f-4f60-84fa-e69bbb117c30
Zaniboni, M.
9bea8449-f073-4409-9169-50d1eaba6f8c

Chalmers, J.R., Thomas, K.S., Apfelbacher, C., Williams, H.C., Prinsen, C.A., Spuls, P.I., Simpson, E., Gerbens, L.A.A., Boers, M., Barbarot, S., Stalder, J.F., Abuabara, K., Aoki, V., Ardeleanu, M., Armstrong, J., Bang, B., Berents, T.L., Burton, T., Butler, L., Chubachi, T., Cresswell-Melville, A., DeLozier, A., Eckert, L., Eichenfield, L., Flohr, C., Futamura, M., Gadkari, A., Gjerde, E.S., van Halewijn, K.F., Hawkes, C., Howells, L., Howie, L., Humphreys, R., Ishii, H.A., Kataoka, Y., Katayama, I., Kouwenhoven, W., Langan, S.M., Leshem, Y.A., Merhand, S., Mina-Osorio, P., Murota, H., Nakahara, T., Nunes, F.P., Nygaard, U., Nygårdas, M., Ohya, Y., Ono, E., Rehbinder, E., Rogers, N.K., Romeijn, G.L.E., Schuttelaar, M.L.A., Sears, A.V., Simpson, M.A., Singh, J.A., Srour, J., Stuart, B., Svensson, , Talmo, G., Talmo, H., Teixeira, H.D., Thyssen, J.P., Todd, G., Torchet, F., Volke, A., von Kobyletzki, L., Weisshaar, E., Wollenberg, A. and Zaniboni, M. (2018) Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178 (5), e332-e341. (doi:10.1111/bjd.16543).

Record type: Article

Abstract

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies. Small-group allocations were performed a priori to ensure that each group included different stakeholders from a variety of geographical regions. Anonymous whole-group voting was carried out using handheld electronic voting pads according to predefined consensus rules. It was agreed by consensus that the long-term control domain should include signs, symptoms, quality of life and a patient global instrument. The group agreed that itch intensity should be measured when assessing long-term control of eczema in addition to the frequency of itch captured by the symptoms domain. There was no recommendation of an instrument for the core outcome domain of quality of life in children, but existing instruments were assessed for face validity and feasibility, and future work that will facilitate the recommendation of an instrument was agreed upon.

Text
Chalmers_et_al-2018-British_Journal_of_Dermatology - Version of Record
Download (326kB)

More information

Accepted/In Press date: 21 January 2018
e-pub ahead of print date: 19 April 2018
Published date: 1 May 2018

Identifiers

Local EPrints ID: 421462
URI: http://eprints.soton.ac.uk/id/eprint/421462
ISSN: 0007-0963
PURE UUID: 5db6a550-cd8c-4038-bf0a-02a742f78d22

Catalogue record

Date deposited: 13 Jun 2018 16:30
Last modified: 16 Dec 2019 18:09

Export record

Altmetrics

Contributors

Author: J.R. Chalmers
Author: K.S. Thomas
Author: C. Apfelbacher
Author: H.C. Williams
Author: C.A. Prinsen
Author: P.I. Spuls
Author: E. Simpson
Author: L.A.A. Gerbens
Author: M. Boers
Author: S. Barbarot
Author: J.F. Stalder
Author: K. Abuabara
Author: V. Aoki
Author: M. Ardeleanu
Author: J. Armstrong
Author: B. Bang
Author: T.L. Berents
Author: T. Burton
Author: L. Butler
Author: T. Chubachi
Author: A. Cresswell-Melville
Author: A. DeLozier
Author: L. Eckert
Author: L. Eichenfield
Author: C. Flohr
Author: M. Futamura
Author: A. Gadkari
Author: E.S. Gjerde
Author: K.F. van Halewijn
Author: C. Hawkes
Author: L. Howells
Author: L. Howie
Author: R. Humphreys
Author: H.A. Ishii
Author: Y. Kataoka
Author: I. Katayama
Author: W. Kouwenhoven
Author: S.M. Langan
Author: Y.A. Leshem
Author: S. Merhand
Author: P. Mina-Osorio
Author: H. Murota
Author: T. Nakahara
Author: F.P. Nunes
Author: U. Nygaard
Author: M. Nygårdas
Author: Y. Ohya
Author: E. Ono
Author: E. Rehbinder
Author: N.K. Rogers
Author: G.L.E. Romeijn
Author: M.L.A. Schuttelaar
Author: A.V. Sears
Author: M.A. Simpson
Author: J.A. Singh
Author: J. Srour
Author: B. Stuart
Author: Svensson
Author: G. Talmo
Author: H. Talmo
Author: H.D. Teixeira
Author: J.P. Thyssen
Author: G. Todd
Author: F. Torchet
Author: A. Volke
Author: L. von Kobyletzki
Author: E. Weisshaar
Author: A. Wollenberg
Author: M. Zaniboni

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×