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The role of n-3 long chain polyunsaturated fatty acids in cardiovascular disease prevention, and interactions with statins

The role of n-3 long chain polyunsaturated fatty acids in cardiovascular disease prevention, and interactions with statins
The role of n-3 long chain polyunsaturated fatty acids in cardiovascular disease prevention, and interactions with statins
Decreases in global cardiovascular disease (CVD) mortality and morbidity in recent decades can be partly attributed to cholesterol reduction through statin use. n-3 long chain polyunsaturated fatty acids are recommended by some authorities for primary and secondary CVD prevention, and for triglyceride reduction. The residual risk of CVD that remains after statin therapy may potentially be reduced by n-3 long chain polyunsaturated fatty acids. However, the effects of concomitant use of statins and n-3 long chain polyunsaturated fatty acids are not well understood. Pleiotropic effects of statins and n-3 long chain polyunsaturated fatty acids overlap. For example, cytochrome P450 enzymes that metabolize statins may affect n-3 long chain polyunsaturated fatty acid metabolism and vice versa. Clinical and mechanistic study results show both synergistic and antagonistic effects of statins and n-3 long chain polyunsaturated fatty acids when used in combination
Bird, Julia K.
947c4936-5f2c-4f84-99ea-8873003dcbf7
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Eggersdorfer, Manfred
b69f6f28-accd-4e30-9a98-520933b8c40d
Bird, Julia K.
947c4936-5f2c-4f84-99ea-8873003dcbf7
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Eggersdorfer, Manfred
b69f6f28-accd-4e30-9a98-520933b8c40d

Bird, Julia K., Calder, Philip and Eggersdorfer, Manfred (2018) The role of n-3 long chain polyunsaturated fatty acids in cardiovascular disease prevention, and interactions with statins. Nutrients, 10 (6), [775]. (doi:10.3390/nu10060775).

Record type: Article

Abstract

Decreases in global cardiovascular disease (CVD) mortality and morbidity in recent decades can be partly attributed to cholesterol reduction through statin use. n-3 long chain polyunsaturated fatty acids are recommended by some authorities for primary and secondary CVD prevention, and for triglyceride reduction. The residual risk of CVD that remains after statin therapy may potentially be reduced by n-3 long chain polyunsaturated fatty acids. However, the effects of concomitant use of statins and n-3 long chain polyunsaturated fatty acids are not well understood. Pleiotropic effects of statins and n-3 long chain polyunsaturated fatty acids overlap. For example, cytochrome P450 enzymes that metabolize statins may affect n-3 long chain polyunsaturated fatty acid metabolism and vice versa. Clinical and mechanistic study results show both synergistic and antagonistic effects of statins and n-3 long chain polyunsaturated fatty acids when used in combination

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Accepted/In Press date: 13 June 2018
e-pub ahead of print date: 15 June 2018
Published date: 15 June 2018

Identifiers

Local EPrints ID: 421513
URI: http://eprints.soton.ac.uk/id/eprint/421513
PURE UUID: 93776538-a749-49aa-8f2f-749d2ced3086
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 14 Jun 2018 16:30
Last modified: 26 Nov 2021 02:38

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Contributors

Author: Julia K. Bird
Author: Philip Calder ORCID iD
Author: Manfred Eggersdorfer

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