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Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes

Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes
Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes
The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material. Detailed investigation of the size and composition of the metal debris contained within these composites requires the digestion of the flakes to release the small metal particles. Here, we compare alkaline and enzymatic digestion methods that both aim to fragment the flakes and reveal their smallest building blocks. The characterisation of debris cleaned with both methods revealed crystalline Cr oxide nanoparticles and clusters. Comparison between the treatments showed that the alkaline method is more efficient in fragmenting the flakes and provided cleaner and generally smaller nanoparticles than exhibited in debris released with the enzymatic treatment. The provision of cleaner nanoparticles from the alkaline method also allows the physicochemical properties of the particles to be more clearly identified.
1552-4981
1-11
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
86e03724-aacc-46d5-bccc-4c7025556667
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
86e03724-aacc-46d5-bccc-4c7025556667
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f

Crainic, Alina-Mariana, Callisti, Mauro, Palmer, Martin and Cook, Richard (2018) Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 1-11. (doi:10.1002/jbm.b.34134).

Record type: Article

Abstract

The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material. Detailed investigation of the size and composition of the metal debris contained within these composites requires the digestion of the flakes to release the small metal particles. Here, we compare alkaline and enzymatic digestion methods that both aim to fragment the flakes and reveal their smallest building blocks. The characterisation of debris cleaned with both methods revealed crystalline Cr oxide nanoparticles and clusters. Comparison between the treatments showed that the alkaline method is more efficient in fragmenting the flakes and provided cleaner and generally smaller nanoparticles than exhibited in debris released with the enzymatic treatment. The provision of cleaner nanoparticles from the alkaline method also allows the physicochemical properties of the particles to be more clearly identified.

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More information

Accepted/In Press date: 23 March 2018
e-pub ahead of print date: 16 April 2018

Identifiers

Local EPrints ID: 421550
URI: http://eprints.soton.ac.uk/id/eprint/421550
ISSN: 1552-4981
PURE UUID: 691bf042-a70e-43ac-8fef-b41eaa4d879e
ORCID for Richard Cook: ORCID iD orcid.org/0000-0002-2468-5820

Catalogue record

Date deposited: 14 Jun 2018 16:31
Last modified: 16 Mar 2024 04:01

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Contributors

Author: Alina-Mariana Crainic
Author: Mauro Callisti
Author: Martin Palmer
Author: Richard Cook ORCID iD

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