The University of Southampton
University of Southampton Institutional Repository

Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes

Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes
Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes
The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material. Detailed investigation of the size and composition of the metal debris contained within these composites requires the digestion of the flakes to release the small metal particles. Here, we compare alkaline and enzymatic digestion methods that both aim to fragment the flakes and reveal their smallest building blocks. The characterisation of debris cleaned with both methods revealed crystalline Cr oxide nanoparticles and clusters. Comparison between the treatments showed that the alkaline method is more efficient in fragmenting the flakes and provided cleaner and generally smaller nanoparticles than exhibited in debris released with the enzymatic treatment. The provision of cleaner nanoparticles from the alkaline method also allows the physicochemical properties of the particles to be more clearly identified.
1552-4981
1-11
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
86e03724-aacc-46d5-bccc-4c7025556667
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
86e03724-aacc-46d5-bccc-4c7025556667
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f

Crainic, Alina-Mariana, Callisti, Mauro, Palmer, Martin and Cook, Richard (2018) Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 1-11. (doi:10.1002/jbm.b.34134).

Record type: Article

Abstract

The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material. Detailed investigation of the size and composition of the metal debris contained within these composites requires the digestion of the flakes to release the small metal particles. Here, we compare alkaline and enzymatic digestion methods that both aim to fragment the flakes and reveal their smallest building blocks. The characterisation of debris cleaned with both methods revealed crystalline Cr oxide nanoparticles and clusters. Comparison between the treatments showed that the alkaline method is more efficient in fragmenting the flakes and provided cleaner and generally smaller nanoparticles than exhibited in debris released with the enzymatic treatment. The provision of cleaner nanoparticles from the alkaline method also allows the physicochemical properties of the particles to be more clearly identified.

Text
Crainic_et_al-2017-Journal_of_Biomedical_Materials_Research_Part_B__Applied_Biomaterials - Version of Record
Restricted to Repository staff only
Request a copy
Text
JBMB_no corrections (002)
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 23 March 2018
e-pub ahead of print date: 16 April 2018

Identifiers

Local EPrints ID: 421550
URI: http://eprints.soton.ac.uk/id/eprint/421550
ISSN: 1552-4981
PURE UUID: 691bf042-a70e-43ac-8fef-b41eaa4d879e

Catalogue record

Date deposited: 14 Jun 2018 16:31
Last modified: 16 Dec 2019 18:20

Export record

Altmetrics

Contributors

Author: Alina-Mariana Crainic
Author: Mauro Callisti
Author: Martin Palmer
Author: Richard Cook

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×