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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function
Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer's disease, Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD) is associated with cognitive function and physical health in the UK Biobank, a cohort of healthy individuals. Group-based analyses were then performed to compare the top and bottom 10% for the three neurodegenerative polygenic risk scores; these groups were compared on the cognitive and physical health variables. Higher polygenic risk for AD, ALS, and FTD was associated with lower cognitive performance. Higher polygenic risk for FTD was also associated with increased forced expiratory volume in 1s and peak expiratory flow. A significant group difference was observed on the symbol digit substitution task between individuals with high polygenic risk for FTD and high polygenic risk for ALS. The results suggest some overlap between polygenic risk for neurodegenerative disorders, cognitive function and physical health.

1932-6203
1-13
Hagenaars, Saskia P.
f5bef8aa-aeef-44bf-be77-43a1dd2dac9d
Radakovic, Ratko
f104ec30-724a-4d5c-aed4-70cbd1cde897
Crockford, Christopher
0c963eb3-feb8-4010-beec-1a06e0584705
Fawns-Ritchie, Chloe
2b19d42d-7f57-49aa-a1d5-43e8c1c567c7
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
International FTD-Genomics Consortium (IFGC)
Hagenaars, Saskia P.
f5bef8aa-aeef-44bf-be77-43a1dd2dac9d
Radakovic, Ratko
f104ec30-724a-4d5c-aed4-70cbd1cde897
Crockford, Christopher
0c963eb3-feb8-4010-beec-1a06e0584705
Fawns-Ritchie, Chloe
2b19d42d-7f57-49aa-a1d5-43e8c1c567c7
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac

Hagenaars, Saskia P., Radakovic, Ratko, Crockford, Christopher, Fawns-Ritchie, Chloe, Harris, Sarah E., Gale, Catharine R. and Deary, Ian J. , International FTD-Genomics Consortium (IFGC) (2018) Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function. PLoS ONE, 13 (6), 1-13. (doi:10.1371/journal.pone.0198187).

Record type: Article

Abstract

Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer's disease, Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD) is associated with cognitive function and physical health in the UK Biobank, a cohort of healthy individuals. Group-based analyses were then performed to compare the top and bottom 10% for the three neurodegenerative polygenic risk scores; these groups were compared on the cognitive and physical health variables. Higher polygenic risk for AD, ALS, and FTD was associated with lower cognitive performance. Higher polygenic risk for FTD was also associated with increased forced expiratory volume in 1s and peak expiratory flow. A significant group difference was observed on the symbol digit substitution task between individuals with high polygenic risk for FTD and high polygenic risk for ALS. The results suggest some overlap between polygenic risk for neurodegenerative disorders, cognitive function and physical health.

Text
journal.pone.0198187
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More information

Accepted/In Press date: 14 May 2018
e-pub ahead of print date: 1 June 2018

Identifiers

Local EPrints ID: 421642
URI: https://eprints.soton.ac.uk/id/eprint/421642
ISSN: 1932-6203
PURE UUID: 32ed9726-aa8d-4511-bdae-aa2596a7b210
ORCID for Catharine R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 19 Jun 2018 16:30
Last modified: 10 Dec 2019 01:54

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Contributors

Author: Saskia P. Hagenaars
Author: Ratko Radakovic
Author: Christopher Crockford
Author: Chloe Fawns-Ritchie
Author: Sarah E. Harris
Author: Ian J. Deary

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