Fitting fulldataset splitting by compound type - excludes pyrrol and triamide compounds
Linear fit with ALOGP and ALOGP2 - excluding NB_quarterly_report_7:13
Squaramides show good model

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Squaramide
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Response Log.1.EC50 Compound_Type=squaramide

Effect Summary
Source	LogWorth	                    	PValue
ALOGP	1.097	++                  	0.07999
ALOGP2	0.408	+                   	0.39060

Summary of Fit
RSquare	0.940684
RSquare Adj	0.916958
Root Mean Square Error	0.200807
Mean of Response	1.026842
Observations (or Sum Wgts)	8

Analysis of Variance
Source	DF	Sum of Squares	Mean Square	F Ratio
Model	2	3.1974348	1.59872	39.6475
Error	5	0.2016164	0.04032		Prob > F
C. Total	7	3.3990512		0.0009	

Parameter Estimates
Term	Estimate	Std Error	t Ratio	Prob>|t|
Intercept	 -1.555758	0.73451	 -2.12	0.0877
ALOGP	0.8800653	0.401668	2.19	0.0800
ALOGP2	 -0.04779	0.050867	 -0.94	0.3906

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Thiourea
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Response Log.1.EC50 Compound_Type=thiourea

Effect Summary
Source	LogWorth	                         	PValue
ALOGP	0.709	++                       	0.19529
ALOGP2	0.388	+                        	0.40972

Lack Of Fit
Source	DF	Sum of Squares	Mean Square	F Ratio
Lack Of Fit	36	16.924511	0.470125	1.3353
Pure Error	2	0.704176	0.352088		Prob > F
Total Error	38	17.628687		0.5199	
					Max RSq
				0.9682	

Summary of Fit	
RSquare	0.203766
RSquare Adj	0.161859
Root Mean Square Error	0.681111
Mean of Response	0.305638
Observations (or Sum Wgts)	41

Analysis of Variance
Source	DF	Sum of Squares	Mean Square	F Ratio
Model	2	4.511388	2.25569	4.8623
Error	38	17.628687	0.46391		Prob > F
C. Total	40	22.140075		0.0132	

Parameter Estimates
Term	Estimate	Std Error	t Ratio	Prob>|t|
Intercept	 -1.594266	1.14122	 -1.40	0.1705
ALOGP	0.4997012	0.379044	1.32	0.1953
ALOGP2	 -0.024035	0.028833	 -0.83	0.4097

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Urea
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Response Log.1.EC50 Compound_Type=urea

Effect Summary
Source	LogWorth	                         	PValue
ALOGP2	0.524	+                        	0.29944
ALOGP	0.327	+                        	0.47128

Lack Of Fit
Source	DF	Sum of Squares	Mean Square	F Ratio
Lack Of Fit	28	32.532733	1.16188	1.5039
Pure Error	1	0.772572	0.77257		Prob > F
Total Error	29	33.305305		0.5783	
					Max RSq
				0.9802	

Summary of Fit
RSquare	0.144632
RSquare Adj	0.085641
Root Mean Square Error	1.071662
Mean of Response	0.625743
Observations (or Sum Wgts)	32

Analysis of Variance
Source	DF	Sum of Squares	Mean Square	F Ratio
Model	2	5.631509	2.81575	2.4518
Error	29	33.305305	1.14846		Prob > F
C. Total	31	38.936814		0.1038	

Parameter Estimates
Term	Estimate	Std Error	t Ratio	Prob>|t|
Intercept	1.2466203	1.78703	0.70	0.4910
ALOGP	 -0.55694	0.762997	 -0.73	0.4713
ALOGP2	0.080586	0.076273	1.06	0.2994
