﻿Model of 19 parameters from AICc stepwise fit modelling for Log(1/EC50)

Response Log10(1/EC50)

Effect Summary
Source	LogWorth	                    	PValue
VE2_X	9.838	++++++++++++++++++++	0.00000
VE2_H2	5.563	+++++++++++         	0.00000
DLS_04	5.374	+++++++++++         	0.00000
LOC	5.138	++++++++++          	0.00001
ChiA_Dz(i)	4.887	++++++++++          	0.00001
P_VSA_MR_2	4.404	+++++++++           	0.00004
RBF	3.089	++++++              	0.00081
Psi_e_0	2.980	++++++              	0.00105
SpMax_B(p)	2.557	+++++               	0.00277
Hy	2.514	+++++               	0.00306
ICR	2.076	++++                	0.00840
J_Dz(p)	1.913	++++                	0.01221
S0K	1.832	++++                	0.01472
SpMax_B(s)	1.382	+++                 	0.04146
SpMaxA_L	0.998	++                  	0.10039
EE_B(m)	0.858	++                  	0.13872
ON0V	0.627	+                   	0.23603
AVS_H2	0.607	+                   	0.24735

Lack Of Fit
Source	DF	Sum of Squares	Mean Square	F Ratio
Lack Of Fit	65	14.568313	0.224128	0.7838
Pure Error	1	0.285957	0.285957		Prob > F
Total Error	66	14.854269		0.7372	
					Max RSq
				0.9964	

Summary of Fit
RSquare	0.813879
RSquare Adj	0.763118
Root Mean Square Error	0.47441
Mean of Response	0.497151
Observations (or Sum Wgts)	85

Analysis of Variance
Source	DF	Sum of Squares	Mean Square	F Ratio
Model	18	64.955351	3.60863	16.0337
Error	66	14.854269	0.22506		Prob > F
C. Total	84	79.809620		<.0001	

Parameter Estimates
Term	Estimate	Std Error	t Ratio	Prob>|t|
Intercept	26.877684	10.68372	2.52	0.0143
DLS_04	 -2.968253	0.59177	 -5.02	<.0001
ICR	2.6934603	0.991301	2.72	0.0084
LOC	1.2351865	0.253592	4.87	<.0001
VE2_X	 -45.56136	6.005026	 -7.59	<.0001
ChiA_Dz(i)	278.47624	59.06627	4.71	<.0001
SpMax_B(p)	 -3.167952	1.019076	 -3.11	0.0028
VE2_H2	 -33.59328	6.547137	 -5.13	<.0001
P_VSA_MR_2	 -0.006624	0.001503	 -4.41	<.0001
RBF	 -14.40767	4.105436	 -3.51	0.0008
EE_B(m)	0.1495119	0.099761	1.50	0.1387
SpMax_B(s)	 -0.147781	0.071067	 -2.08	0.0415
AVS_H2	 -2.003821	1.716864	 -1.17	0.2474
SpMaxA_L	 -10.12722	6.077658	 -1.67	0.1004
Psi_e_0	0.1556085	0.045378	3.43	0.0010
S0K	 -0.026417	0.010546	 -2.50	0.0147
Hy	0.7298601	0.237368	3.07	0.0031
J_Dz(p)	1.7222827	0.668299	2.58	0.0122
ON0V	 -0.188196	0.157373	 -1.20	0.2360