﻿Model of 14 parameters from BIC stepwise fit modelling for Log(1/EC50)

Response Log10(1/EC50)

Effect Summary
Source	LogWorth	                    	PValue
LOC	10.911	+++++++++++         	0.00000
VE2_X	9.739	++++++++++          	0.00000
DLS_04	8.914	+++++++++           	0.00000
VE2_H2	8.185	++++++++            	0.00000
RBF	6.908	+++++++             	0.00000
P_VSA_MR_2	5.816	++++++              	0.00000
SpMax_B(p)	4.055	++++                	0.00009
AVS_H2	3.783	++++                	0.00016
ChiA_Dz(i)	3.299	+++                 	0.00050
EE_B(m)	1.707	++                  	0.01962
SpMaxA_L	1.575	++                  	0.02662
SpMax_B(s)	1.058	+                   	0.08745
ICR	0.264	                    	0.54413

Lack Of Fit
Source	DF	Sum of Squares	Mean Square	F Ratio
Lack Of Fit	70	18.425199	0.263217	0.9205
Pure Error	1	0.285957	0.285957		Prob > F
Total Error	71	18.711155		0.6991	
					Max RSq
				0.9964	

Summary of Fit
RSquare	0.765553
RSquare Adj	0.722626
Root Mean Square Error	0.513359
Mean of Response	0.497151
Observations (or Sum Wgts)	85

Analysis of Variance
Source	DF	Sum of Squares	Mean Square	F Ratio
Model	13	61.098465	4.69988	17.8338
Error	71	18.711155	0.26354		Prob > F
C. Total	84	79.809620		<.0001	

Parameter Estimates
Term	Estimate	Std Error	t Ratio	Prob>|t|
Intercept	56.74629	7.6738	7.39	<.0001
DLS_04	 -3.427166	0.49022	 -6.99	<.0001
ICR	 -0.311508	0.51108	 -0.61	0.5441
LOC	1.2196429	0.151084	8.07	<.0001
VE2_X	 -41.99638	5.645099	 -7.44	<.0001
ChiA_Dz(i)	184.54129	50.60249	3.65	0.0005
SpMax_B(p)	 -4.260218	1.024228	 -4.16	<.0001
VE2_H2	 -42.31192	6.419249	 -6.59	<.0001
P_VSA_MR_2	 -0.006516	0.001242	 -5.25	<.0001
RBF	 -21.21442	3.608904	 -5.88	<.0001
EE_B(m)	0.2417459	0.101246	2.39	0.0196
SpMax_B(s)	 -0.104105	0.060074	 -1.73	0.0874
AVS_H2	 -5.813968	1.461068	 -3.98	0.0002
SpMaxA_L	 -14.1364	6.243627	 -2.26	0.0266