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Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk

Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk
Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk

Magnetic nano drug targeting, through the use of an external magnetic field, is a new technique for the treatment of several diseases, which can potentially avoid the dispersion of drugs in undesired locations of the body. Nevertheless, due to the limitations on the intensity of the magnetic field applied, the hydrodynamic forces can reduce the effectiveness of the procedure. This technique is studied in this paper with the Computational Fluid Dynamics (CFD), focusing on the influence of the magnetic probe position, and the direction of the circulating electric current. A single rectangular coil is used to generate the external magnetic field. A patient-specific geometry of the coeliac trunk is reconstructed from DICOM images, with the use of VMTK. A new solver, coupling the Lagrangian dynamics of the nanoparticles with the Eulerian dynamics of the blood, is implemented in OpenFOAM to perform the simulations. The resistive pressure, the Womersley's profile for the inlet velocity and the magnetic field of a rectangular coil are implemented in the software as boundary conditions. The results show the influence of the position of the probe, as well as the limitations associated with the rectangular coil configuration.

Coeliac trunk, Eulerian model, Lagrangian model, Magnetic hydro dynamics, Nanoparticles, Patient-specific
0304-8853
86-97
Boghi, Andrea
54a72da6-c8a2-468c-9773-897efac0638f
Russo, Flavia
9d2ad280-80b0-439e-bcf2-acc5b07ca1bd
Gori, Fabio
f7e76614-37d8-4c3b-b7b0-8c6603a4515f
Boghi, Andrea
54a72da6-c8a2-468c-9773-897efac0638f
Russo, Flavia
9d2ad280-80b0-439e-bcf2-acc5b07ca1bd
Gori, Fabio
f7e76614-37d8-4c3b-b7b0-8c6603a4515f

Boghi, Andrea, Russo, Flavia and Gori, Fabio (2017) Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk. Journal of Magnetism and Magnetic Materials, 437, 86-97. (doi:10.1016/j.jmmm.2017.04.055).

Record type: Article

Abstract

Magnetic nano drug targeting, through the use of an external magnetic field, is a new technique for the treatment of several diseases, which can potentially avoid the dispersion of drugs in undesired locations of the body. Nevertheless, due to the limitations on the intensity of the magnetic field applied, the hydrodynamic forces can reduce the effectiveness of the procedure. This technique is studied in this paper with the Computational Fluid Dynamics (CFD), focusing on the influence of the magnetic probe position, and the direction of the circulating electric current. A single rectangular coil is used to generate the external magnetic field. A patient-specific geometry of the coeliac trunk is reconstructed from DICOM images, with the use of VMTK. A new solver, coupling the Lagrangian dynamics of the nanoparticles with the Eulerian dynamics of the blood, is implemented in OpenFOAM to perform the simulations. The resistive pressure, the Womersley's profile for the inlet velocity and the magnetic field of a rectangular coil are implemented in the software as boundary conditions. The results show the influence of the position of the probe, as well as the limitations associated with the rectangular coil configuration.

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More information

Accepted/In Press date: 21 April 2017
e-pub ahead of print date: 26 April 2017
Published date: 1 September 2017
Keywords: Coeliac trunk, Eulerian model, Lagrangian model, Magnetic hydro dynamics, Nanoparticles, Patient-specific

Identifiers

Local EPrints ID: 421757
URI: https://eprints.soton.ac.uk/id/eprint/421757
ISSN: 0304-8853
PURE UUID: 59abdd70-e3dd-4774-8bf3-b61af942ede0
ORCID for Andrea Boghi: ORCID iD orcid.org/0000-0002-9387-326X

Catalogue record

Date deposited: 26 Jun 2018 16:30
Last modified: 14 Mar 2019 02:00

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