Modelling three-dimensional cochlear micromechanics within the Guinea pig organ of Corti

Ni, Guangjian and Elliott, Stephen J. (2018) Modelling three-dimensional cochlear micromechanics within the Guinea pig organ of Corti. In To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. vol. 1965, American Institute of Physics.. (doi:10.1063/1.5038525).

Abstract

The active amplification process in the mammalian cochlea depends on a complex interaction between cells within the organ of Corti. A three-dimensional (3D) model was developed using the finite element method based on anatomy for the apical end in the guinea pig cochlea, which is comprised of 3D discrete hair cells, 3D continuous membranes and fluid. The basilar membrane, tectorial membrane and the reticular lamina are modelled with orthotropic materials. The Y-shape structures formed by the outer hair cell (OHC), the Deiters' cell and Deiters' cell phalangeal process are also included to account for the structural longitudinal coupling. The motion within the organ of Corti was first simulated in response to a pressure difference loading on the basilar membrane, in order to calculate the passive vibration pattern. Then, the outer hair cells somatic electromotility was implemented by applying a voltage across the OHC walls to investigate its contribution to membranes motion.

This record has no associated files available for download.

Contributors

Author: Guangjian Ni

Download statistics