A review of novel technologies and techniques associated with identification of bloodstream infection etiologies and rapid antimicrobial genotypic and quantitative phenotypic determination
A review of novel technologies and techniques associated with identification of bloodstream infection etiologies and rapid antimicrobial genotypic and quantitative phenotypic determination
Introduction: The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and identification of bacteria with antimicrobial susceptibility is crucial to direct therapy early in the course of illness. Molecular techniques offer a potential solution to this. Areas covered: In the present review the authors have discussed a number of novel solutions utilizing a variety of molecular techniques for pathogen detection, identification and antimicrobial susceptibility. The review is not designed to be an exhaustive literature review covering all diagnostic solutions ever developed, instead the authors have focused on what they have had experience using, evaluating or currently view as new and exciting with potential to revolutionize BSI diagnosis. The authors searched PubMed (Medline) and Google Scholar with terms: BSI, Bacteraemia, Candidaemia, Diagnostics, AST, Rapid, AMR, Novel and Blood Culture. The authors attended recent clinical microbiology technology congresses. Expert commentary: There are multiple exciting novel technologies at differing stages of development with potential to revolutionize diagnosis of BSI. More work is needed as well as a standardized assessment of different platforms in order to better understand the clinical and financial impacts these will have in clinical microbiology laboratories.
Accelerate, antimicrobial susceptibility, Blood stream infections, PCR, rapid diagnostics
543-555
Poole, Stephen
eae07d5b-3402-4454-b473-712110c9d866
Kidd, Stephen P.
1409c55c-35d2-4a0b-8ef2-2370e6bf1dee
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
3 June 2018
Poole, Stephen
eae07d5b-3402-4454-b473-712110c9d866
Kidd, Stephen P.
1409c55c-35d2-4a0b-8ef2-2370e6bf1dee
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Poole, Stephen, Kidd, Stephen P. and Saeed, Kordo
(2018)
A review of novel technologies and techniques associated with identification of bloodstream infection etiologies and rapid antimicrobial genotypic and quantitative phenotypic determination.
Expert Review of Molecular Diagnostics, 18 (6), .
(doi:10.1080/14737159.2018.1480369).
Abstract
Introduction: The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and identification of bacteria with antimicrobial susceptibility is crucial to direct therapy early in the course of illness. Molecular techniques offer a potential solution to this. Areas covered: In the present review the authors have discussed a number of novel solutions utilizing a variety of molecular techniques for pathogen detection, identification and antimicrobial susceptibility. The review is not designed to be an exhaustive literature review covering all diagnostic solutions ever developed, instead the authors have focused on what they have had experience using, evaluating or currently view as new and exciting with potential to revolutionize BSI diagnosis. The authors searched PubMed (Medline) and Google Scholar with terms: BSI, Bacteraemia, Candidaemia, Diagnostics, AST, Rapid, AMR, Novel and Blood Culture. The authors attended recent clinical microbiology technology congresses. Expert commentary: There are multiple exciting novel technologies at differing stages of development with potential to revolutionize diagnosis of BSI. More work is needed as well as a standardized assessment of different platforms in order to better understand the clinical and financial impacts these will have in clinical microbiology laboratories.
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Accepted/In Press date: 21 May 2018
e-pub ahead of print date: 23 May 2018
Published date: 3 June 2018
Keywords:
Accelerate, antimicrobial susceptibility, Blood stream infections, PCR, rapid diagnostics
Identifiers
Local EPrints ID: 421971
URI: http://eprints.soton.ac.uk/id/eprint/421971
ISSN: 1473-7159
PURE UUID: cf01d2ca-5d34-4b4d-8493-44bf83b8af6a
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Date deposited: 12 Jul 2018 16:30
Last modified: 16 Mar 2024 04:41
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Author:
Stephen Poole
Author:
Stephen P. Kidd
Author:
Kordo Saeed
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