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Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance.
2045-7634
3800-3811
Whitton, Bradleigh
352554cc-cbf8-4d58-8c8f-51721abfe743
Okamoto, Haruko
cea35380-7618-44c8-a268-47b0198cc7f9
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373
Whitton, Bradleigh
352554cc-cbf8-4d58-8c8f-51721abfe743
Okamoto, Haruko
cea35380-7618-44c8-a268-47b0198cc7f9
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373

Whitton, Bradleigh, Okamoto, Haruko, Packham, Graham and Crabb, Simon (2018) Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer. Cancer Medicine, 7 (8), 3800-3811. (doi:10.1002/cam4.1594).

Record type: Review

Abstract

Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance.

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More information

Accepted/In Press date: 8 May 2018
e-pub ahead of print date: 21 June 2018
Published date: August 2018

Identifiers

Local EPrints ID: 422002
URI: https://eprints.soton.ac.uk/id/eprint/422002
ISSN: 2045-7634
PURE UUID: f0ded486-18b4-4b87-9c3c-e0c3579805e2
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 12 Jul 2018 16:31
Last modified: 14 Mar 2019 01:47

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