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Regulation of the meiotic divisions of mammalian oocytes and eggs

Regulation of the meiotic divisions of mammalian oocytes and eggs
Regulation of the meiotic divisions of mammalian oocytes and eggs
Initiated by luteinising hormone and finalised by the fertilizing sperm, the mammalian oocyte completes its two meiotic divisions. The first division occurs in the mature Graafian follicle during the hours preceding ovulation and culminates in an extreme asymmetric cell division and the segregation of the two pairs of homologous chromosomes. The newly-created mature egg re-arrests at metaphase of the second meiotic division prior to ovulation and only completes meiosis following a Ca2+ signal initiated by the sperm at gamete fusion. Here we review the cellular events that govern the passage of the oocyte through meiosis I with a focus on the role of the Spindle Assembly Checkpoint (SAC) in regulating its timing. In meiosis II we examine how the egg achieves its arrest and how the fertilization Ca2+ signal allows initiation of embryo development.
0300-5127
797-806
Sanders, Jessica
57db3eef-7515-4f7d-a4af-512805d647cb
Jones, Keith
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4
Sanders, Jessica
57db3eef-7515-4f7d-a4af-512805d647cb
Jones, Keith
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4

Sanders, Jessica and Jones, Keith (2018) Regulation of the meiotic divisions of mammalian oocytes and eggs. Biochemical Society Transactions, 46 (4), 797-806. (doi:10.1042/BST20170493).

Record type: Review

Abstract

Initiated by luteinising hormone and finalised by the fertilizing sperm, the mammalian oocyte completes its two meiotic divisions. The first division occurs in the mature Graafian follicle during the hours preceding ovulation and culminates in an extreme asymmetric cell division and the segregation of the two pairs of homologous chromosomes. The newly-created mature egg re-arrests at metaphase of the second meiotic division prior to ovulation and only completes meiosis following a Ca2+ signal initiated by the sperm at gamete fusion. Here we review the cellular events that govern the passage of the oocyte through meiosis I with a focus on the role of the Spindle Assembly Checkpoint (SAC) in regulating its timing. In meiosis II we examine how the egg achieves its arrest and how the fertilization Ca2+ signal allows initiation of embryo development.

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More information

Accepted/In Press date: 30 May 2018
e-pub ahead of print date: 22 June 2018
Published date: August 2018

Identifiers

Local EPrints ID: 422026
URI: http://eprints.soton.ac.uk/id/eprint/422026
ISSN: 0300-5127
PURE UUID: a58c9a95-dcb0-4282-9fbd-a96960113f9d
ORCID for Keith Jones: ORCID iD orcid.org/0000-0002-0294-0851

Catalogue record

Date deposited: 12 Jul 2018 16:31
Last modified: 26 Nov 2021 02:59

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Contributors

Author: Jessica Sanders
Author: Keith Jones ORCID iD

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