New developments in the enantioselective synthesis of spiro compounds
New developments in the enantioselective synthesis of spiro compounds
The enantioselective synthesis of spirocycles has long been pursued by organic chemists. Despite their unique 3D properties and presence in several natural products, the difficulty in their enantioselective synthesis makes them underrepresented in pharmaceutical libraries. Since the first pioneering reports of the enantioselective construction of spirosilanes by Tamao et al., significant effort has been devoted towards the development of new promising asymmetric methodologies. Remarkably, with the advent of organocatalysis, particularly over six years, the reported methodologies for the synthesis of spirocycles have increased exponentially. The aim of this review is to summarize the latest trends and developments in the enantioselective synthesis of spirocompounds during these last six years.
5946-5996
Meazza, Marta
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Ding, Aishun
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Guo, Hao
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Yang, Jung Woon
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Rios, Ramon
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Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Ding, Aishun
be81855a-9636-47f4-8f6d-bd2564bdb2d7
Guo, Hao
2e060524-1e5c-47e7-8ee6-b81d25f82d0d
Yang, Jung Woon
70327194-b21c-402c-83c0-4474fb47db63
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Meazza, Marta, Ding, Aishun, Guo, Hao, Yang, Jung Woon and Rios, Ramon
(2018)
New developments in the enantioselective synthesis of spiro compounds.
Chemical Society Reviews, 47 (15), .
(doi:10.1039/c6cs00825a).
Abstract
The enantioselective synthesis of spirocycles has long been pursued by organic chemists. Despite their unique 3D properties and presence in several natural products, the difficulty in their enantioselective synthesis makes them underrepresented in pharmaceutical libraries. Since the first pioneering reports of the enantioselective construction of spirosilanes by Tamao et al., significant effort has been devoted towards the development of new promising asymmetric methodologies. Remarkably, with the advent of organocatalysis, particularly over six years, the reported methodologies for the synthesis of spirocycles have increased exponentially. The aim of this review is to summarize the latest trends and developments in the enantioselective synthesis of spirocompounds during these last six years.
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Revision_2018.05.25_YJW_
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Accepted/In Press date: 17 December 2017
e-pub ahead of print date: 29 June 2018
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Local EPrints ID: 422303
URI: http://eprints.soton.ac.uk/id/eprint/422303
ISSN: 0306-0012
PURE UUID: 2e33ddcd-08fb-4acf-8408-62e8f15aff23
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Date deposited: 20 Jul 2018 16:30
Last modified: 16 Mar 2024 06:50
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Author:
Marta Meazza
Author:
Aishun Ding
Author:
Hao Guo
Author:
Jung Woon Yang
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