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A cohort study reporting normal oximetry values in healthy infants under 4 months of age using Masimo technology

A cohort study reporting normal oximetry values in healthy infants under 4 months of age using Masimo technology
A cohort study reporting normal oximetry values in healthy infants under 4 months of age using Masimo technology

Objective: To determine sleeping saturation indices in healthy infants using a modern pulse oximeter with motion artefact extraction technology. 

Design: Prospective cohort. 

Setting: Home. 

Subjects: Healthy term infants. Intervention: Nocturnal pulse oximetry at home at 1 month of age (Recording 1) and repeated at age 3-4 months (Recording 2). Parents documented sleep times. Visi-Download software (Stowood Scientific) analysed data with artefact and wake periods removed. 

Main outcome measures: Saturations (SAT50), desaturation index >4% (DI4) and >3% (DI3) from baseline/hour, delta index 12 s (DI12s), minimum saturations (SATmin), percentage time with saturations below 90% and 92%. 

Results: Forty-five babies were studied at 1 month and 38 babies at 3-4 months. Mean (CI) SAT50, DI4, DI3, DI12s and SATmin (CI) were 97.05 (96.59 to 97.52), 16.16 (13.72 to 18.59), 25.41 (22.00 to 28.82), 0.96 (0.88 to 1.04) and 80.4% (78.8% to 82.0%) at 1 month, respectively, and 97.65 (97.19 to 98.12), 8.12 (6.46 to 9.77), 13.92 (11.38 to 16.47), 0.72 (0.65 to 0.78) and 84.7% (83.3% to 86.1%) at 3-4 months. Median (CI) percentage times with saturations below 90% and 92% were 0.39 (0.26 to 0.55) and 0.82 (0.60 to 1.23), respectively, at 1 month and 0.11 (0.06 to 0.20) and 0.25 (0.17 to 0.44) at 3-4 months. For paired samples (n=32) DI4 (P=0.006), DI3 (P=0.03), DI12s (P=0.001), percentage time with saturations below 90% (P=0.001) and 92% (P=0.000) all fell significantly and SATmin (P=0.004) rose between the two recordings. 

Conclusion: Desaturation indices are substantially higher in young infants than older children where a DI4 over 4 is considered abnormal. These decrease by 3-4 months of age but still remain elevated compared with older children.

respiratory
0003-9888
Evans, Hazel J.
11506bb3-ce57-41fa-9966-0b22131a1a35
Karunatilleke, Anne S.
f401d307-58ef-417e-a7a7-d049cd6dc243
Grantham-Hill, Sarah
d159cb71-c30a-4185-96c6-d7a083b94887
Gavlak, Johanna C.
7bdc0a38-81bb-4b26-8356-272860d9209e
Evans, Hazel J.
11506bb3-ce57-41fa-9966-0b22131a1a35
Karunatilleke, Anne S.
f401d307-58ef-417e-a7a7-d049cd6dc243
Grantham-Hill, Sarah
d159cb71-c30a-4185-96c6-d7a083b94887
Gavlak, Johanna C.
7bdc0a38-81bb-4b26-8356-272860d9209e

Evans, Hazel J., Karunatilleke, Anne S., Grantham-Hill, Sarah and Gavlak, Johanna C. (2018) A cohort study reporting normal oximetry values in healthy infants under 4 months of age using Masimo technology. Archives of Disease in Childhood. (doi:10.1136/archdischild-2017-314361).

Record type: Article

Abstract

Objective: To determine sleeping saturation indices in healthy infants using a modern pulse oximeter with motion artefact extraction technology. 

Design: Prospective cohort. 

Setting: Home. 

Subjects: Healthy term infants. Intervention: Nocturnal pulse oximetry at home at 1 month of age (Recording 1) and repeated at age 3-4 months (Recording 2). Parents documented sleep times. Visi-Download software (Stowood Scientific) analysed data with artefact and wake periods removed. 

Main outcome measures: Saturations (SAT50), desaturation index >4% (DI4) and >3% (DI3) from baseline/hour, delta index 12 s (DI12s), minimum saturations (SATmin), percentage time with saturations below 90% and 92%. 

Results: Forty-five babies were studied at 1 month and 38 babies at 3-4 months. Mean (CI) SAT50, DI4, DI3, DI12s and SATmin (CI) were 97.05 (96.59 to 97.52), 16.16 (13.72 to 18.59), 25.41 (22.00 to 28.82), 0.96 (0.88 to 1.04) and 80.4% (78.8% to 82.0%) at 1 month, respectively, and 97.65 (97.19 to 98.12), 8.12 (6.46 to 9.77), 13.92 (11.38 to 16.47), 0.72 (0.65 to 0.78) and 84.7% (83.3% to 86.1%) at 3-4 months. Median (CI) percentage times with saturations below 90% and 92% were 0.39 (0.26 to 0.55) and 0.82 (0.60 to 1.23), respectively, at 1 month and 0.11 (0.06 to 0.20) and 0.25 (0.17 to 0.44) at 3-4 months. For paired samples (n=32) DI4 (P=0.006), DI3 (P=0.03), DI12s (P=0.001), percentage time with saturations below 90% (P=0.001) and 92% (P=0.000) all fell significantly and SATmin (P=0.004) rose between the two recordings. 

Conclusion: Desaturation indices are substantially higher in young infants than older children where a DI4 over 4 is considered abnormal. These decrease by 3-4 months of age but still remain elevated compared with older children.

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More information

Accepted/In Press date: 25 February 2018
e-pub ahead of print date: 24 March 2018
Keywords: respiratory

Identifiers

Local EPrints ID: 422447
URI: http://eprints.soton.ac.uk/id/eprint/422447
ISSN: 0003-9888
PURE UUID: d0a105e0-41fd-4bca-ba21-36264d7d09a9
ORCID for Hazel J. Evans: ORCID iD orcid.org/0000-0001-9366-556X

Catalogue record

Date deposited: 24 Jul 2018 16:30
Last modified: 16 Mar 2024 04:35

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Contributors

Author: Hazel J. Evans ORCID iD
Author: Anne S. Karunatilleke
Author: Sarah Grantham-Hill
Author: Johanna C. Gavlak

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