A systems perspective on placental amino acid transport
A systems perspective on placental amino acid transport
Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which may have lifelong health consequences. Trans-epithelial transfer of amino acids across the placental syncytiotrophoblast requires accumulative, exchange and facilitated transporters on the apical and basal membranes to work in concert. However, transporters alone do not determine amino acid transfer and factors that affect substrate availability, such as blood flow and metabolism may also become rate-limiting for transfer. In order to determine the rate-limiting processes, it is necessary to take a systems approach which recognises the interdependence of these processes. New technologies have the potential to deliver targeted interventions to the placenta and help poorly growing fetuses. While many factors are necessary for amino acid transfer, novel therapies need to target the rate-limiting factors if they are going to be effective. This review will outline the factors which determine amino acid transfer and describe how they become interdependent. It will also highlight the role of computational modelling as a tool to understand this process. This article is protected by copyright. All rights reserved.
Journal Article
5511-5522
Cleal, Jane K.
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Lofthouse, Emma M.
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Sengers, Bram G.
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Lewis, Rohan M.
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1 December 2018
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lofthouse, Emma M.
c4004ff1-2ed3-4b80-9ade-583c742de59c
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, Jane K., Lofthouse, Emma M., Sengers, Bram G. and Lewis, Rohan M.
(2018)
A systems perspective on placental amino acid transport.
The Journal of Physiology, 596 (23), .
(doi:10.1113/JP274883).
Abstract
Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which may have lifelong health consequences. Trans-epithelial transfer of amino acids across the placental syncytiotrophoblast requires accumulative, exchange and facilitated transporters on the apical and basal membranes to work in concert. However, transporters alone do not determine amino acid transfer and factors that affect substrate availability, such as blood flow and metabolism may also become rate-limiting for transfer. In order to determine the rate-limiting processes, it is necessary to take a systems approach which recognises the interdependence of these processes. New technologies have the potential to deliver targeted interventions to the placenta and help poorly growing fetuses. While many factors are necessary for amino acid transfer, novel therapies need to target the rate-limiting factors if they are going to be effective. This review will outline the factors which determine amino acid transfer and describe how they become interdependent. It will also highlight the role of computational modelling as a tool to understand this process. This article is protected by copyright. All rights reserved.
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Cleal et al 2018 The Journal of Physiology
- Accepted Manuscript
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JP274883
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Accepted/In Press date: 5 June 2018
e-pub ahead of print date: 8 July 2018
Published date: 1 December 2018
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Journal Article
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Local EPrints ID: 422458
URI: http://eprints.soton.ac.uk/id/eprint/422458
ISSN: 0022-3751
PURE UUID: d50ad6b2-f67f-4aa0-9693-21232827661e
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Date deposited: 24 Jul 2018 16:30
Last modified: 16 Mar 2024 06:53
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Author:
Emma M. Lofthouse
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