The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

A systems perspective on placental amino acid transport

A systems perspective on placental amino acid transport
A systems perspective on placental amino acid transport

Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which may have lifelong health consequences. Trans-epithelial transfer of amino acids across the placental syncytiotrophoblast requires accumulative, exchange and facilitated transporters on the apical and basal membranes to work in concert. However, transporters alone do not determine amino acid transfer and factors that affect substrate availability, such as blood flow and metabolism may also become rate-limiting for transfer. In order to determine the rate-limiting processes, it is necessary to take a systems approach which recognises the interdependence of these processes. New technologies have the potential to deliver targeted interventions to the placenta and help poorly growing fetuses. While many factors are necessary for amino acid transfer, novel therapies need to target the rate-limiting factors if they are going to be effective. This review will outline the factors which determine amino acid transfer and describe how they become interdependent. It will also highlight the role of computational modelling as a tool to understand this process. This article is protected by copyright. All rights reserved.

Journal Article
0022-3751
5511-5522
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lofthouse, Emma M.
c4004ff1-2ed3-4b80-9ade-583c742de59c
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lofthouse, Emma M.
c4004ff1-2ed3-4b80-9ade-583c742de59c
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502

Cleal, Jane K., Lofthouse, Emma M., Sengers, Bram G. and Lewis, Rohan M. (2018) A systems perspective on placental amino acid transport. The Journal of Physiology, 596 (23), 5511-5522. (doi:10.1113/JP274883).

Record type: Review

Abstract

Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which may have lifelong health consequences. Trans-epithelial transfer of amino acids across the placental syncytiotrophoblast requires accumulative, exchange and facilitated transporters on the apical and basal membranes to work in concert. However, transporters alone do not determine amino acid transfer and factors that affect substrate availability, such as blood flow and metabolism may also become rate-limiting for transfer. In order to determine the rate-limiting processes, it is necessary to take a systems approach which recognises the interdependence of these processes. New technologies have the potential to deliver targeted interventions to the placenta and help poorly growing fetuses. While many factors are necessary for amino acid transfer, novel therapies need to target the rate-limiting factors if they are going to be effective. This review will outline the factors which determine amino acid transfer and describe how they become interdependent. It will also highlight the role of computational modelling as a tool to understand this process. This article is protected by copyright. All rights reserved.

Text
Cleal et al 2018 The Journal of Physiology - Accepted Manuscript
Download (1MB)
Text
JP274883 - Version of Record
Available under License Creative Commons Attribution.
Download (826kB)

More information

Accepted/In Press date: 5 June 2018
e-pub ahead of print date: 8 July 2018
Published date: 1 December 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 422458
URI: http://eprints.soton.ac.uk/id/eprint/422458
ISSN: 0022-3751
PURE UUID: d50ad6b2-f67f-4aa0-9693-21232827661e
ORCID for Jane K. Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for Emma M. Lofthouse: ORCID iD orcid.org/0000-0002-0175-5590
ORCID for Bram G. Sengers: ORCID iD orcid.org/0000-0001-5859-6984
ORCID for Rohan M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104

Catalogue record

Date deposited: 24 Jul 2018 16:30
Last modified: 26 Nov 2021 06:47

Export record

Altmetrics

Contributors

Author: Jane K. Cleal ORCID iD
Author: Emma M. Lofthouse ORCID iD
Author: Bram G. Sengers ORCID iD
Author: Rohan M. Lewis ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×