Association of height growth in puberty with lung function: A longitudinal study
Association of height growth in puberty with lung function: A longitudinal study
RATIONALE: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.
OBJECTIVES: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early-adulthood.
METHODS: Longitudinal analyses of repeat height measurements from age 5-20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterise height growth trajectories, and derive pubertal age and peak height velocity using the validated SuperImposition by Translation and Rotation (SITAR) model. Association of these estimates with pre-bronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75 at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.
MEASUREMENTS AND MAIN RESULTS: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year advanced pubertal age was associated with a 263 ml higher FVC (95% confidence interval: 167, 360) for males (n=567), 100 ml (50, 150) for females (n=990). A 1-cm/year increase in peak velocity was associated with 145 ml (56, 234) and 50 ml (2, 99) increase in FVC for males and females respectively. No associations were found with FEV1/FVC.
CONCLUSIONS: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.
Journal Article
1539-1548
Mahmoud, Osama
cea428a7-081f-4a76-aabe-8ff1cf558ebc
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Tilling, Kate
016f1a6c-9568-4211-84d4-019f2c1d7b38
Minelli, Cosetta
e9c228b2-b94c-4763-bb62-5acb94a7a50b
Garcia-Aymerich, Judith
db1f2bf3-b293-45e6-aaa7-2f7a6fe9b593
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Sterne, Jonathan
05fbcb78-68a6-4461-815e-e1f555602bd5
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36
15 December 2018
Mahmoud, Osama
cea428a7-081f-4a76-aabe-8ff1cf558ebc
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Tilling, Kate
016f1a6c-9568-4211-84d4-019f2c1d7b38
Minelli, Cosetta
e9c228b2-b94c-4763-bb62-5acb94a7a50b
Garcia-Aymerich, Judith
db1f2bf3-b293-45e6-aaa7-2f7a6fe9b593
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Sterne, Jonathan
05fbcb78-68a6-4461-815e-e1f555602bd5
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36
Mahmoud, Osama, Granell, Raquel, Tilling, Kate, Minelli, Cosetta, Garcia-Aymerich, Judith, Holloway, John W., Custovic, Adnan, Jarvis, Deborah, Sterne, Jonathan and Henderson, John
(2018)
Association of height growth in puberty with lung function: A longitudinal study.
American Journal of Respiratory and Critical Care Medicine, 198 (12), .
(doi:10.1164/rccm.201802-0274OC).
Abstract
RATIONALE: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.
OBJECTIVES: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early-adulthood.
METHODS: Longitudinal analyses of repeat height measurements from age 5-20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterise height growth trajectories, and derive pubertal age and peak height velocity using the validated SuperImposition by Translation and Rotation (SITAR) model. Association of these estimates with pre-bronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75 at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.
MEASUREMENTS AND MAIN RESULTS: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year advanced pubertal age was associated with a 263 ml higher FVC (95% confidence interval: 167, 360) for males (n=567), 100 ml (50, 150) for females (n=990). A 1-cm/year increase in peak velocity was associated with 145 ml (56, 234) and 50 ml (2, 99) increase in FVC for males and females respectively. No associations were found with FEV1/FVC.
CONCLUSIONS: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.
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- Accepted Manuscript
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OM_Supp_ht_Pub_LF_Marked_UP
- Accepted Manuscript
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Accepted/In Press date: 6 July 2018
e-pub ahead of print date: 11 July 2018
Published date: 15 December 2018
Keywords:
Journal Article
Identifiers
Local EPrints ID: 422470
URI: http://eprints.soton.ac.uk/id/eprint/422470
ISSN: 1073-449X
PURE UUID: d4b2b658-e941-436c-8ad3-2c50e4e817d6
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Date deposited: 24 Jul 2018 16:30
Last modified: 16 Mar 2024 06:52
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Contributors
Author:
Osama Mahmoud
Author:
Raquel Granell
Author:
Kate Tilling
Author:
Cosetta Minelli
Author:
Judith Garcia-Aymerich
Author:
Adnan Custovic
Author:
Deborah Jarvis
Author:
Jonathan Sterne
Author:
John Henderson
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