The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Association of height growth in puberty with lung function: A longitudinal study

Association of height growth in puberty with lung function: A longitudinal study
Association of height growth in puberty with lung function: A longitudinal study

RATIONALE: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.

OBJECTIVES: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early-adulthood.

METHODS: Longitudinal analyses of repeat height measurements from age 5-20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterise height growth trajectories, and derive pubertal age and peak height velocity using the validated SuperImposition by Translation and Rotation (SITAR) model. Association of these estimates with pre-bronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75 at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.

MEASUREMENTS AND MAIN RESULTS: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year advanced pubertal age was associated with a 263 ml higher FVC (95% confidence interval: 167, 360) for males (n=567), 100 ml (50, 150) for females (n=990). A 1-cm/year increase in peak velocity was associated with 145 ml (56, 234) and 50 ml (2, 99) increase in FVC for males and females respectively. No associations were found with FEV1/FVC.

CONCLUSIONS: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.

Journal Article
1073-449X
1539-1548
Mahmoud, Osama
cea428a7-081f-4a76-aabe-8ff1cf558ebc
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Tilling, Kate
016f1a6c-9568-4211-84d4-019f2c1d7b38
Minelli, Cosetta
e9c228b2-b94c-4763-bb62-5acb94a7a50b
Garcia-Aymerich, Judith
db1f2bf3-b293-45e6-aaa7-2f7a6fe9b593
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Sterne, Jonathan
05fbcb78-68a6-4461-815e-e1f555602bd5
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36
Mahmoud, Osama
cea428a7-081f-4a76-aabe-8ff1cf558ebc
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Tilling, Kate
016f1a6c-9568-4211-84d4-019f2c1d7b38
Minelli, Cosetta
e9c228b2-b94c-4763-bb62-5acb94a7a50b
Garcia-Aymerich, Judith
db1f2bf3-b293-45e6-aaa7-2f7a6fe9b593
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Sterne, Jonathan
05fbcb78-68a6-4461-815e-e1f555602bd5
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36

Mahmoud, Osama, Granell, Raquel, Tilling, Kate, Minelli, Cosetta, Garcia-Aymerich, Judith, Holloway, John W., Custovic, Adnan, Jarvis, Deborah, Sterne, Jonathan and Henderson, John (2018) Association of height growth in puberty with lung function: A longitudinal study. American Journal of Respiratory and Critical Care Medicine, 198 (12), 1539-1548. (doi:10.1164/rccm.201802-0274OC).

Record type: Article

Abstract

RATIONALE: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.

OBJECTIVES: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early-adulthood.

METHODS: Longitudinal analyses of repeat height measurements from age 5-20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterise height growth trajectories, and derive pubertal age and peak height velocity using the validated SuperImposition by Translation and Rotation (SITAR) model. Association of these estimates with pre-bronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75 at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.

MEASUREMENTS AND MAIN RESULTS: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year advanced pubertal age was associated with a 263 ml higher FVC (95% confidence interval: 167, 360) for males (n=567), 100 ml (50, 150) for females (n=990). A 1-cm/year increase in peak velocity was associated with 145 ml (56, 234) and 50 ml (2, 99) increase in FVC for males and females respectively. No associations were found with FEV1/FVC.

CONCLUSIONS: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.

Text
OM_Manuscript_ht_Pub_LF_Marked_UP - Accepted Manuscript
Download (467kB)
Text
OM_Supp_ht_Pub_LF_Marked_UP - Accepted Manuscript
Download (668kB)

More information

Accepted/In Press date: 6 July 2018
e-pub ahead of print date: 11 July 2018
Published date: 15 December 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 422470
URI: http://eprints.soton.ac.uk/id/eprint/422470
ISSN: 1073-449X
PURE UUID: d4b2b658-e941-436c-8ad3-2c50e4e817d6
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 24 Jul 2018 16:30
Last modified: 26 Nov 2021 06:27

Export record

Altmetrics

Contributors

Author: Osama Mahmoud
Author: Raquel Granell
Author: Kate Tilling
Author: Cosetta Minelli
Author: Judith Garcia-Aymerich
Author: Adnan Custovic
Author: Deborah Jarvis
Author: Jonathan Sterne
Author: John Henderson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×