Rosacea-like eruption due to topical pimecrolimus
Rosacea-like eruption due to topical pimecrolimus
Topical calcineurin inhibitors have been used outside their approved indications for a number of conditions, including topical steroid-induced rosacea. However, tacrolimus ointment itself has been reported to trigger rosacea in a small number of cases. We report a case of a rosacea-like eruption in a 39-year-old woman occurring after the use of pimecrolimus cream for 12 months for atopic dermatitis. Withdrawal of pimecrolimus combined with treatment with oral lymecycline, topical metronidazole, and an emollient resulted in resolution of the eruption. There have been 5 previously reported cases of a topical pimecrolimus-induced rosacea-like eruption suggesting that this rare side-effect may be a class effect of all topical calcineurin inhibitors. Dermatologists prescribing these drugs should be aware of this uncommon complication and may wish to warn patients of its occurrence as a potential side-effect when using topical calcineurin inhibitors in facial skin in adults.
Administration, Cutaneous, Adult, Dermatologic Agents, Drug Eruptions, Facial Dermatoses, Female, Humans, Peptidylprolyl Isomerase, Rosacea, Tacrolimus, Case Reports, Letter
1-3
El-Heis, S.
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Buckley, D A
cdba6eba-dbdc-400d-814a-b7f14e33d4ba
18 May 2015
El-Heis, S.
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Buckley, D A
cdba6eba-dbdc-400d-814a-b7f14e33d4ba
El-Heis, S. and Buckley, D A
(2015)
Rosacea-like eruption due to topical pimecrolimus.
Dermatology Online Journal, 21 (5), .
Abstract
Topical calcineurin inhibitors have been used outside their approved indications for a number of conditions, including topical steroid-induced rosacea. However, tacrolimus ointment itself has been reported to trigger rosacea in a small number of cases. We report a case of a rosacea-like eruption in a 39-year-old woman occurring after the use of pimecrolimus cream for 12 months for atopic dermatitis. Withdrawal of pimecrolimus combined with treatment with oral lymecycline, topical metronidazole, and an emollient resulted in resolution of the eruption. There have been 5 previously reported cases of a topical pimecrolimus-induced rosacea-like eruption suggesting that this rare side-effect may be a class effect of all topical calcineurin inhibitors. Dermatologists prescribing these drugs should be aware of this uncommon complication and may wish to warn patients of its occurrence as a potential side-effect when using topical calcineurin inhibitors in facial skin in adults.
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Published date: 18 May 2015
Keywords:
Administration, Cutaneous, Adult, Dermatologic Agents, Drug Eruptions, Facial Dermatoses, Female, Humans, Peptidylprolyl Isomerase, Rosacea, Tacrolimus, Case Reports, Letter
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Local EPrints ID: 422483
URI: http://eprints.soton.ac.uk/id/eprint/422483
ISSN: 1087-2108
PURE UUID: 64f5fde8-2053-4a30-88e1-2caa6e883bc2
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Date deposited: 24 Jul 2018 16:30
Last modified: 16 Mar 2024 04:21
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Author:
S. El-Heis
Author:
D A Buckley
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