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The colorectal cancer microenvironment: strategies for studying the role of cancer-associated fibroblasts

The colorectal cancer microenvironment: strategies for studying the role of cancer-associated fibroblasts
The colorectal cancer microenvironment: strategies for studying the role of cancer-associated fibroblasts

Colorectal cancer (CRC) is a key public health concern and the second highest cause of cancer related death in Western society. A dynamic interaction exists between CRC cells and the surrounding tumor microenvironment, which can stimulate not only the development of CRC, but its progression and metastasis, as well as the development of resistance to therapy. In this chapter, we focus on the role of fibroblasts within the CRC tumor microenvironment and describe some of the key methods for their study, as well as the evaluation of dynamic interactions within this biological ecosystem.

Cancer-associated fibroblasts, Colorectal cancer, Extracellular vesicles, Tumor microenvironment
1064-3745
87-98
Humana Press Inc.
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Mellone, Massimiliano
b0301b32-14f8-4203-9026-b7f90885cab9
Emo, Katherine
ae0ee96d-2d3e-4833-aef3-2ea5a75a8a94
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Sayan, A. Emre
5590c6d1-6562-46be-a002-98adc087f1b6
Mirnezami, Alex H.
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Beaulieu, Jean-François
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Mellone, Massimiliano
b0301b32-14f8-4203-9026-b7f90885cab9
Emo, Katherine
ae0ee96d-2d3e-4833-aef3-2ea5a75a8a94
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Sayan, A. Emre
5590c6d1-6562-46be-a002-98adc087f1b6
Mirnezami, Alex H.
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Beaulieu, Jean-François

Bhome, Rahul, Mellone, Massimiliano, Emo, Katherine, Thomas, Gareth J., Sayan, A. Emre and Mirnezami, Alex H. (2018) The colorectal cancer microenvironment: strategies for studying the role of cancer-associated fibroblasts. In, Beaulieu, Jean-François (ed.) Colorectal Cancer : Methods and Protocols. (Methods in Molecular Biology, , (doi:10.1007/978-1-4939-7765-9_6), 1765) New York, NY. Humana Press Inc., pp. 87-98. (doi:10.1007/978-1-4939-7765-9_6).

Record type: Book Section

Abstract

Colorectal cancer (CRC) is a key public health concern and the second highest cause of cancer related death in Western society. A dynamic interaction exists between CRC cells and the surrounding tumor microenvironment, which can stimulate not only the development of CRC, but its progression and metastasis, as well as the development of resistance to therapy. In this chapter, we focus on the role of fibroblasts within the CRC tumor microenvironment and describe some of the key methods for their study, as well as the evaluation of dynamic interactions within this biological ecosystem.

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More information

e-pub ahead of print date: 27 March 2018
Published date: 2018
Keywords: Cancer-associated fibroblasts, Colorectal cancer, Extracellular vesicles, Tumor microenvironment

Identifiers

Local EPrints ID: 422507
URI: https://eprints.soton.ac.uk/id/eprint/422507
ISSN: 1064-3745
PURE UUID: 3ce26db7-215b-45cf-9919-2b5eb9f33505
ORCID for Massimiliano Mellone: ORCID iD orcid.org/0000-0002-4964-9340

Catalogue record

Date deposited: 24 Jul 2018 16:31
Last modified: 14 Mar 2019 01:38

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