The University of Southampton
University of Southampton Institutional Repository

Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort

Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort
Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort
Background: In severe asthma, the presence of airway eosinophilia is a key “treatable trait”. Airway eosinophilia may be proximal or distal, however work on predictors of airway eosinophilia have focussed on the proximal compartment which is less invasive to sample.

The Wessex Severe Asthma Cohort (WSAC) included 342 severe asthmatics for detailed phenotyping, including bronchoalveolar lavage (BAL) and sputum induction in some participants. We aimed to use data from WSAC to determine the most accurate non-invasive predictor of eosinophilia in participants with severe asthma.

Method: Severe asthmatics in WSAC were included if they underwent BAL or successful sputum induction. The value of Fraction of Exhaled Nitric Oxide (FeNO), blood eosinophil count and periostin in predicting sputum or BAL eosinophilia (3% or 1% respectively) were assessed using Receiver Operating Characteristic (ROC) curves.

Results: All three measures were more accurate at predicting BAL than sputum eosinophilia. FeNO demonstrated a higher predictive value than the other measures in both compartments. Optimal thresholds were similar across compartments for FeNO but more divergent for periostin and blood.

Conclusion: Within this cohort, FeNO was the strongest predictor of sputum or BAL eosinophilia. All factors assessed were stronger at predicting BAL eosinophilia than sputum.
0903-1936
Jones, Thomas
2ed43a38-d65d-4786-9208-a1e1298ce413
Brown, Thomas
fdd42359-a39d-4f22-b48d-015d9b94ec76
Elliott, Scott
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Gove, Kerry
6493b359-21cd-4068-88f4-a6e684f73316
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Ono, Junya
ca04523f-02e6-4274-aefe-3c4bac46a8e6
Izuhara, Kenji
cf69a8d3-6644-4bad-b27f-7d0abae2b0af
Jones, Thomas
2ed43a38-d65d-4786-9208-a1e1298ce413
Brown, Thomas
fdd42359-a39d-4f22-b48d-015d9b94ec76
Elliott, Scott
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Gove, Kerry
6493b359-21cd-4068-88f4-a6e684f73316
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Ono, Junya
ca04523f-02e6-4274-aefe-3c4bac46a8e6
Izuhara, Kenji
cf69a8d3-6644-4bad-b27f-7d0abae2b0af

Jones, Thomas, Brown, Thomas, Elliott, Scott, Barber, Clair, Gove, Kerry, Lau, Laurie, Rupani, Hitasha, Chauhan, Anoop, Howarth, Peter, Ono, Junya and Izuhara, Kenji (2017) Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort. European Respiratory Journal, 50 (Suppl 61), [PA4765].

Record type: Meeting abstract

Abstract

Background: In severe asthma, the presence of airway eosinophilia is a key “treatable trait”. Airway eosinophilia may be proximal or distal, however work on predictors of airway eosinophilia have focussed on the proximal compartment which is less invasive to sample.

The Wessex Severe Asthma Cohort (WSAC) included 342 severe asthmatics for detailed phenotyping, including bronchoalveolar lavage (BAL) and sputum induction in some participants. We aimed to use data from WSAC to determine the most accurate non-invasive predictor of eosinophilia in participants with severe asthma.

Method: Severe asthmatics in WSAC were included if they underwent BAL or successful sputum induction. The value of Fraction of Exhaled Nitric Oxide (FeNO), blood eosinophil count and periostin in predicting sputum or BAL eosinophilia (3% or 1% respectively) were assessed using Receiver Operating Characteristic (ROC) curves.

Results: All three measures were more accurate at predicting BAL than sputum eosinophilia. FeNO demonstrated a higher predictive value than the other measures in both compartments. Optimal thresholds were similar across compartments for FeNO but more divergent for periostin and blood.

Conclusion: Within this cohort, FeNO was the strongest predictor of sputum or BAL eosinophilia. All factors assessed were stronger at predicting BAL eosinophilia than sputum.

This record has no associated files available for download.

More information

Published date: September 2017
Venue - Dates: European Respiratory Society International Congress, , Milan, Italy, 2017-09-09 - 2017-09-13

Identifiers

Local EPrints ID: 422514
URI: http://eprints.soton.ac.uk/id/eprint/422514
ISSN: 0903-1936
PURE UUID: 3b119b11-1276-4ca6-bac3-045eb061292a
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129

Catalogue record

Date deposited: 25 Jul 2018 16:30
Last modified: 15 Mar 2024 21:00

Export record

Contributors

Author: Thomas Jones
Author: Thomas Brown
Author: Scott Elliott
Author: Clair Barber ORCID iD
Author: Kerry Gove
Author: Laurie Lau
Author: Hitasha Rupani
Author: Anoop Chauhan
Author: Peter Howarth
Author: Junya Ono
Author: Kenji Izuhara

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×