The University of Southampton
University of Southampton Institutional Repository

Characteristics of eosinophilic severe asthmatics in the Wessex Severe Asthma Cohort (WSAC)

Characteristics of eosinophilic severe asthmatics in the Wessex Severe Asthma Cohort (WSAC)
Characteristics of eosinophilic severe asthmatics in the Wessex Severe Asthma Cohort (WSAC)
Background: Severe asthma is a complex amalgam of phenotypes and comorbidities. Most novel therapies target type 2 disease so determining the optimal treatment for each patient will likely require detailed phenotyping. The WSAC study recruited 491 participants split between severe asthma (n=342), mild asthma (n=69) and healthy controls (n=80) for detailed phenotyping; inclusion criteria were asthma diagnosed as per guidelines and at least 1 exacerbation in 12 months. Smokers and those with comorbidity were included in order to reflect clinical practice. We aimed to assess the differences in demographic and clinical characteristics between participants with eosinophilic and non-eosinophilic severe asthma in the WSAC.
Methods: WSAC participants with severe asthma (BTS Step 4-5) were included for analysis if they underwent successful sputum induction. Demographics, medication use, comorbidities, FEV1, FeNO, Asthma Control Questionnaire 6 (ACQ6) score and exacerbation frequency were compared between eosinophilic and non-eosinophilic groups.
Results: 210 participants provided sputum, of which 86 (41%) had sputum eosinophils over 3%. These participants were more likely to be male (52% vs 29%) and never smokers(59% vs 45%), had lower median FEV1(68% vs 77% predicted) and BMI(28.2 vs 31.8) but higher FeNO(32 vs 16ppb) and were less likely to use antidepressants(13% vs 27%) or reflux treatment(39% vs 55%) (all P<0.05). Annual exacerbation rate(3.2 vs 3.0), past Intensive Care Unit admission(18% vs 17%), ACQ6(2.7 vs 2.9) and ICS dose were not significantly different.
Conclusion: Severe asthmatics with sputum eosinophilia despite high-dose ICS have poorer lung function but less obesity, depression and reflux
0903-1936
Jones, Thomas
2ed43a38-d65d-4786-9208-a1e1298ce413
Brown, Thomas
fdd42359-a39d-4f22-b48d-015d9b94ec76
Elliott, Scott
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Gove, Kerry
6493b359-21cd-4068-88f4-a6e684f73316
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Jones, Thomas
2ed43a38-d65d-4786-9208-a1e1298ce413
Brown, Thomas
fdd42359-a39d-4f22-b48d-015d9b94ec76
Elliott, Scott
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Gove, Kerry
6493b359-21cd-4068-88f4-a6e684f73316
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21

Jones, Thomas, Brown, Thomas, Elliott, Scott, Rupani, Hitasha, Chauhan, Anoop, Barber, Clair, Gove, Kerry, Lau, Laurie and Howarth, Peter (2017) Characteristics of eosinophilic severe asthmatics in the Wessex Severe Asthma Cohort (WSAC). European Respiratory Journal, 50 (Suppl 61).

Record type: Meeting abstract

Abstract

Background: Severe asthma is a complex amalgam of phenotypes and comorbidities. Most novel therapies target type 2 disease so determining the optimal treatment for each patient will likely require detailed phenotyping. The WSAC study recruited 491 participants split between severe asthma (n=342), mild asthma (n=69) and healthy controls (n=80) for detailed phenotyping; inclusion criteria were asthma diagnosed as per guidelines and at least 1 exacerbation in 12 months. Smokers and those with comorbidity were included in order to reflect clinical practice. We aimed to assess the differences in demographic and clinical characteristics between participants with eosinophilic and non-eosinophilic severe asthma in the WSAC.
Methods: WSAC participants with severe asthma (BTS Step 4-5) were included for analysis if they underwent successful sputum induction. Demographics, medication use, comorbidities, FEV1, FeNO, Asthma Control Questionnaire 6 (ACQ6) score and exacerbation frequency were compared between eosinophilic and non-eosinophilic groups.
Results: 210 participants provided sputum, of which 86 (41%) had sputum eosinophils over 3%. These participants were more likely to be male (52% vs 29%) and never smokers(59% vs 45%), had lower median FEV1(68% vs 77% predicted) and BMI(28.2 vs 31.8) but higher FeNO(32 vs 16ppb) and were less likely to use antidepressants(13% vs 27%) or reflux treatment(39% vs 55%) (all P<0.05). Annual exacerbation rate(3.2 vs 3.0), past Intensive Care Unit admission(18% vs 17%), ACQ6(2.7 vs 2.9) and ICS dose were not significantly different.
Conclusion: Severe asthmatics with sputum eosinophilia despite high-dose ICS have poorer lung function but less obesity, depression and reflux

Full text not available from this repository.

More information

Published date: September 2017
Venue - Dates: European Respiratory Society Annual Congress 2017, Milan, Italy, 2017-09-09 - 2017-09-13

Identifiers

Local EPrints ID: 422515
URI: https://eprints.soton.ac.uk/id/eprint/422515
ISSN: 0903-1936
PURE UUID: 968c0605-4801-44a3-ace4-2c30a2dccd35
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129

Catalogue record

Date deposited: 25 Jul 2018 16:30
Last modified: 14 Mar 2019 01:27

Export record

Contributors

Author: Thomas Jones
Author: Thomas Brown
Author: Scott Elliott
Author: Hitasha Rupani
Author: Anoop Chauhan
Author: Clair Barber ORCID iD
Author: Kerry Gove
Author: Laurie Lau
Author: Peter Howarth

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×