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Serum periostin in asthma: A potential biomarker for stratification in severe treatment-resistant asthma

Serum periostin in asthma: A potential biomarker for stratification in severe treatment-resistant asthma
Serum periostin in asthma: A potential biomarker for stratification in severe treatment-resistant asthma
Rationale: Serum periostin has been proposed as a biomarker of Th2 airway inflammation in asthma. We thus measured serum periostin in a large cohort of patients with severe asthma as well as in those with milder asthma and healthy controls, to gain insight into the value of this biomarker in asthma stratification.Methods: Serum samples from 126 healthy controls (HC), 93 non-steroid treated mild asthmatics (MA), 35 asthmatics on low dose corticosteroids +/- LABA (ModA) and 276 severe treatment-resistant asthmatics (SA) were assayed for serum periostin by ELISA (Shino-Test Corporation, Kanagawa, Japan) and the results related to clinical and inflammatory markers. Results: Group median serum periostin levels were significantly (p<0.0001) lower in both the steroid treated asthma groups (ModA and SA) than the HC or MA groups, although there was greater spread in SA with 21% of values ± the normal range. Tertile analysis of the SA serum periostin identified that those in the upper tertile (≥79 ng/ml) had significantly higher sputum eosinophils (p=0.001), peripheral blood eosinophilia (p=0.002), FeNO (p=0,001) and total IgE (p=0.01) as well as lower FEV1 % predicted (p=0.02) than those in the lowest tertile (≤58ng/ml). Serum periostin measures did not appear related to age, BMI or atopic status.Conclusion: Steroid treatment in asthma is associated with significantly lower serum periostin measures than in non-steroid treated asthma, although a sub-population of severe asthmatics have levels that associate with eosinophilic inflammation.Funding: WSAC was funded by the Medical Research Council UK.
0903-1936
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Ono, Junya
ca04523f-02e6-4274-aefe-3c4bac46a8e6
Ohta, Shoichiro
042f953e-8480-476a-b122-78f01390b80a
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Elliott, Scott P
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Brown, Tom
fdd42359-a39d-4f22-b48d-015d9b94ec76
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Izuhara, Kenji
cf69a8d3-6644-4bad-b27f-7d0abae2b0af
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Rupani, Hitasha
cbc7068a-4279-4c8e-b83f-353210711062
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Ono, Junya
ca04523f-02e6-4274-aefe-3c4bac46a8e6
Ohta, Shoichiro
042f953e-8480-476a-b122-78f01390b80a
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Elliott, Scott P
f3234b8e-63df-45b3-a832-26b9a1acaf7f
Brown, Tom
fdd42359-a39d-4f22-b48d-015d9b94ec76
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Chauhan, Anoop
4f606144-8948-4f82-8cb1-e57e7a05a8ed
Izuhara, Kenji
cf69a8d3-6644-4bad-b27f-7d0abae2b0af
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21

Rupani, Hitasha, Lau, Laurie, Ono, Junya, Ohta, Shoichiro, Barber, Clair, Elliott, Scott P, Brown, Tom, Kurukulaaratchy, Ramesh, Chauhan, Anoop, Izuhara, Kenji and Howarth, Peter (2014) Serum periostin in asthma: A potential biomarker for stratification in severe treatment-resistant asthma. European Respiratory Journal, 44 (Suppl 58).

Record type: Meeting abstract

Abstract

Rationale: Serum periostin has been proposed as a biomarker of Th2 airway inflammation in asthma. We thus measured serum periostin in a large cohort of patients with severe asthma as well as in those with milder asthma and healthy controls, to gain insight into the value of this biomarker in asthma stratification.Methods: Serum samples from 126 healthy controls (HC), 93 non-steroid treated mild asthmatics (MA), 35 asthmatics on low dose corticosteroids +/- LABA (ModA) and 276 severe treatment-resistant asthmatics (SA) were assayed for serum periostin by ELISA (Shino-Test Corporation, Kanagawa, Japan) and the results related to clinical and inflammatory markers. Results: Group median serum periostin levels were significantly (p<0.0001) lower in both the steroid treated asthma groups (ModA and SA) than the HC or MA groups, although there was greater spread in SA with 21% of values ± the normal range. Tertile analysis of the SA serum periostin identified that those in the upper tertile (≥79 ng/ml) had significantly higher sputum eosinophils (p=0.001), peripheral blood eosinophilia (p=0.002), FeNO (p=0,001) and total IgE (p=0.01) as well as lower FEV1 % predicted (p=0.02) than those in the lowest tertile (≤58ng/ml). Serum periostin measures did not appear related to age, BMI or atopic status.Conclusion: Steroid treatment in asthma is associated with significantly lower serum periostin measures than in non-steroid treated asthma, although a sub-population of severe asthmatics have levels that associate with eosinophilic inflammation.Funding: WSAC was funded by the Medical Research Council UK.

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Published date: September 2014
Venue - Dates: Munich European Respiratory Society Congress, 2014-09-06 - 2014-09-10

Identifiers

Local EPrints ID: 422524
URI: https://eprints.soton.ac.uk/id/eprint/422524
ISSN: 0903-1936
PURE UUID: 6283d505-ae7b-4a9c-8fc6-a201a74b9a6d
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129

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Date deposited: 25 Jul 2018 16:30
Last modified: 14 Mar 2019 01:28

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Contributors

Author: Hitasha Rupani
Author: Laurie Lau
Author: Junya Ono
Author: Shoichiro Ohta
Author: Clair Barber ORCID iD
Author: Scott P Elliott
Author: Tom Brown
Author: Ramesh Kurukulaaratchy
Author: Anoop Chauhan
Author: Kenji Izuhara
Author: Peter Howarth

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