Obesity: adipogenesis and insulin resistance
Obesity: adipogenesis and insulin resistance
This meeting focused on the recent developments in the fields of adipogensis and insulin resistance. In particular, the molecular mechanisms presented were those that are likely to be relevant as drug discovery targets for the treatment of obesity and diabetes. New compounds included the LIFR antagonist, hLIF05, and LG- 100641, a selective antagonist of PPARgamma but with insulin sensitizing actions in adipocytes. The small insulin sensitizers discussed were CLX-0901, isolated from plant extracts and currently in phase I clinical trials, TLK-17411, a small synthetic compound and S-15261, which increases insulin sensitivity.
Journal Article
884-886
Sethi, J.K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
August 2000
Sethi, J.K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Sethi, J.K.
(2000)
Obesity: adipogenesis and insulin resistance.
iDrugs : the investigational drugs journal, 3 (8), .
Abstract
This meeting focused on the recent developments in the fields of adipogensis and insulin resistance. In particular, the molecular mechanisms presented were those that are likely to be relevant as drug discovery targets for the treatment of obesity and diabetes. New compounds included the LIFR antagonist, hLIF05, and LG- 100641, a selective antagonist of PPARgamma but with insulin sensitizing actions in adipocytes. The small insulin sensitizers discussed were CLX-0901, isolated from plant extracts and currently in phase I clinical trials, TLK-17411, a small synthetic compound and S-15261, which increases insulin sensitivity.
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Published date: August 2000
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Journal Article
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Local EPrints ID: 422589
URI: http://eprints.soton.ac.uk/id/eprint/422589
ISSN: 1369-7056
PURE UUID: 6aa8dae4-4062-46aa-a35f-54825c59a2a6
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Date deposited: 25 Jul 2018 16:30
Last modified: 28 Feb 2024 03:00
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