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Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parental nutrition.

Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parental nutrition.
Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parental nutrition.
Emerging evidence suggests taurolidine reduces the risk of repeated episodes of catheter related blood stream infections (CRBSI) in a subgroup of patients receiving home parenteral nutrition (HPN). We defined 3 indications where taurolidine could be considered and retrospectively analysed data from patients who were treated over a 10 year period to examine the validity of these criteria. Twenty-two patients were identified from a total HPN population of 81, representing 33.2 years of experience. The overall CRBSI rate pre- and post-taurolidine usage was reduced from 5.71 to 0.99 infections per 1000 patient parenteral nutrition days (P-value <0.0001), with reductions identified in each smaller subgroup, confirming previous reports of a significant reduction in infections when taurolidine is used as secondary prophylaxis and providing initial data suggesting the benefit of its use as primary prophylaxis.
0954-3007
282–284
Saunders, J.
ea422d2d-8d24-4c7f-99a3-517dd9dc4820
Naghibi, M.
aff9b441-3424-42de-8526-3e45da5e820d
Leach, Z.
79ed4265-a69b-45bf-a553-78073139cbd1
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
King, A.
fa854228-cd1f-42ca-bc66-a5c9a5fb9291
Smith, T.
5c23f31c-0ce2-4583-8e24-6f4e308d4352
Stroud, M.
1665ae65-0898-4848-bf0d-baec8f2bb078
Saunders, J.
ea422d2d-8d24-4c7f-99a3-517dd9dc4820
Naghibi, M.
aff9b441-3424-42de-8526-3e45da5e820d
Leach, Z.
79ed4265-a69b-45bf-a553-78073139cbd1
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
King, A.
fa854228-cd1f-42ca-bc66-a5c9a5fb9291
Smith, T.
5c23f31c-0ce2-4583-8e24-6f4e308d4352
Stroud, M.
1665ae65-0898-4848-bf0d-baec8f2bb078

Saunders, J., Naghibi, M., Leach, Z., Parsons, Camille, King, A., Smith, T. and Stroud, M. (2015) Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parental nutrition. European Journal of Clinical Nutrition, 69, 282–284. (doi:10.1038/ejcn.2014.32).

Record type: Article

Abstract

Emerging evidence suggests taurolidine reduces the risk of repeated episodes of catheter related blood stream infections (CRBSI) in a subgroup of patients receiving home parenteral nutrition (HPN). We defined 3 indications where taurolidine could be considered and retrospectively analysed data from patients who were treated over a 10 year period to examine the validity of these criteria. Twenty-two patients were identified from a total HPN population of 81, representing 33.2 years of experience. The overall CRBSI rate pre- and post-taurolidine usage was reduced from 5.71 to 0.99 infections per 1000 patient parenteral nutrition days (P-value <0.0001), with reductions identified in each smaller subgroup, confirming previous reports of a significant reduction in infections when taurolidine is used as secondary prophylaxis and providing initial data suggesting the benefit of its use as primary prophylaxis.

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More information

e-pub ahead of print date: 19 March 2014
Published date: 2015

Identifiers

Local EPrints ID: 422646
URI: http://eprints.soton.ac.uk/id/eprint/422646
ISSN: 0954-3007
PURE UUID: 315fc33e-b95e-4cf9-8319-2e429feaf48f

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Date deposited: 27 Jul 2018 16:30
Last modified: 15 Mar 2024 20:52

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Contributors

Author: J. Saunders
Author: M. Naghibi
Author: Z. Leach
Author: Camille Parsons
Author: A. King
Author: T. Smith
Author: M. Stroud

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