The University of Southampton
University of Southampton Institutional Repository

Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015

Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015
Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015

BACKGROUND: Rotavirus is a leading cause of morbidity and mortality in young children worldwide. In China, the universal immunization of children with the rotavirus vaccine has not been introduced, and the two globally distributed vaccines (RotaTeq and Rotarix) are not licensed in the country. We aim to determine the prevalence and strain diversity of rotavirus in children with diarrhea aged ≤ five years across China.

MATERIALS AND METHODS: Sentinel-based surveillance of acute diarrhea was conducted at 213 participating hospitals in China from January 1, 2009, through December 31, 2015. Group A rotavirus (RVA) was tested by using enzyme-linked immunosorbent assays, and G- and P-genotype of RVA were tested by RT-PCR methods.

RESULTS: Of 33,616 children with diarrhea, 10,089 (30%) were positive for RVA; RVA-associated diarrhea was identified in 2247 (39.5%, n = 2247/5685) inpatients and 7842 (28.1%, n = 7842/27931) outpatients. Children living in low-middle-income regions suffered from the highest burden of rotavirus, with 40.7% of diarrhea cases attributed to rotavirus infection, followed by 31.3% in upper-middle-income and 11.2% in high-income regions. The majority of children (88.9%, n = 8976/10089) who tested positive for RVA were children aged ≤ 2 years. The seasonal peak of RVA was in the winter. Among all 2533 RVA strains genotyped, five strain combinations, G9P[8], G3P[8], G1P[8], G2P[4] and G3P[4], contributed to 71.3% (1807/2533) of the RVA-associated diarrhea cases. The predominant strain of RVA has rapidly evolved from G3P[8] and G1P[8] to G9P[8] in the recent years, with the proportion of G9P[8] having increased remarkably from 3.4% in 2009 to 60.9% in 2015.

CONCLUSIONS: The burden of diarrhea attributed to rotavirus is high in China, highlighting the potential value of vaccination. The rapid shift of RVA strains highlights the importance of conducting rotavirus surveillance to ensure that currently marketed vaccines provide protective efficacy against the circulating strains.

Journal Article
0163-4453
Yu, Jianxing
992198dd-6055-4905-ab28-11ced790c57c
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Geng, Qibin
8c0f930c-f49f-40df-b954-fddd27eb9a76
Ye, Chuchu
0e79dfa4-9258-4907-84f2-b46865129a9a
Zhang, Zike
85c05276-59dd-4033-82c9-4d33e872906b
Zheng, Yaming
e3ef516d-f4f3-4f71-9eb2-39d162215b5d
Wang, Liping
ef5828b8-d874-42db-bb25-713890281af2
Duan, Zhaojun
c09b7c4a-5a41-46f6-b340-578e7ae85463
Zhang, Jing
d6afba24-5cbe-4ff1-967f-486e75419b99
Wu, Shuyu
d7558fad-cebf-4aee-b7b7-7741d3ba97e4
Parashar, Umesh
5ccc393c-a206-4819-be78-585f306968e9
Yang, Weizhong
65d18fbc-d752-42a7-ac38-01534ceda15c
Liao, Qiaohong
8fa88aa8-8b17-47a4-92b4-7f231beb7b8b
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f
Yu, Jianxing
992198dd-6055-4905-ab28-11ced790c57c
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Geng, Qibin
8c0f930c-f49f-40df-b954-fddd27eb9a76
Ye, Chuchu
0e79dfa4-9258-4907-84f2-b46865129a9a
Zhang, Zike
85c05276-59dd-4033-82c9-4d33e872906b
Zheng, Yaming
e3ef516d-f4f3-4f71-9eb2-39d162215b5d
Wang, Liping
ef5828b8-d874-42db-bb25-713890281af2
Duan, Zhaojun
c09b7c4a-5a41-46f6-b340-578e7ae85463
Zhang, Jing
d6afba24-5cbe-4ff1-967f-486e75419b99
Wu, Shuyu
d7558fad-cebf-4aee-b7b7-7741d3ba97e4
Parashar, Umesh
5ccc393c-a206-4819-be78-585f306968e9
Yang, Weizhong
65d18fbc-d752-42a7-ac38-01534ceda15c
Liao, Qiaohong
8fa88aa8-8b17-47a4-92b4-7f231beb7b8b
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f

Yu, Jianxing, Lai, Shengjie, Geng, Qibin, Ye, Chuchu, Zhang, Zike, Zheng, Yaming, Wang, Liping, Duan, Zhaojun, Zhang, Jing, Wu, Shuyu, Parashar, Umesh, Yang, Weizhong, Liao, Qiaohong and Li, Zhongjie (2018) Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015. Journal of Infection. (doi:10.1016/j.jinf.2018.07.004).

Record type: Article

Abstract

BACKGROUND: Rotavirus is a leading cause of morbidity and mortality in young children worldwide. In China, the universal immunization of children with the rotavirus vaccine has not been introduced, and the two globally distributed vaccines (RotaTeq and Rotarix) are not licensed in the country. We aim to determine the prevalence and strain diversity of rotavirus in children with diarrhea aged ≤ five years across China.

MATERIALS AND METHODS: Sentinel-based surveillance of acute diarrhea was conducted at 213 participating hospitals in China from January 1, 2009, through December 31, 2015. Group A rotavirus (RVA) was tested by using enzyme-linked immunosorbent assays, and G- and P-genotype of RVA were tested by RT-PCR methods.

RESULTS: Of 33,616 children with diarrhea, 10,089 (30%) were positive for RVA; RVA-associated diarrhea was identified in 2247 (39.5%, n = 2247/5685) inpatients and 7842 (28.1%, n = 7842/27931) outpatients. Children living in low-middle-income regions suffered from the highest burden of rotavirus, with 40.7% of diarrhea cases attributed to rotavirus infection, followed by 31.3% in upper-middle-income and 11.2% in high-income regions. The majority of children (88.9%, n = 8976/10089) who tested positive for RVA were children aged ≤ 2 years. The seasonal peak of RVA was in the winter. Among all 2533 RVA strains genotyped, five strain combinations, G9P[8], G3P[8], G1P[8], G2P[4] and G3P[4], contributed to 71.3% (1807/2533) of the RVA-associated diarrhea cases. The predominant strain of RVA has rapidly evolved from G3P[8] and G1P[8] to G9P[8] in the recent years, with the proportion of G9P[8] having increased remarkably from 3.4% in 2009 to 60.9% in 2015.

CONCLUSIONS: The burden of diarrhea attributed to rotavirus is high in China, highlighting the potential value of vaccination. The rapid shift of RVA strains highlights the importance of conducting rotavirus surveillance to ensure that currently marketed vaccines provide protective efficacy against the circulating strains.

Text
2018-JI-Prevalence of Rotavirus and Rapid Changes in Circulating Rotavirus Strains among Children with Acute Diarrhea in China, 2009-2015 - Accepted Manuscript
Restricted to Repository staff only until 12 July 2019.
Request a copy

More information

Submitted date: 2 March 2018
Accepted/In Press date: 1 July 2018
e-pub ahead of print date: 12 July 2018
Additional Information: Copyright © 2018. Published by Elsevier Ltd.
Keywords: Journal Article

Identifiers

Local EPrints ID: 422728
URI: https://eprints.soton.ac.uk/id/eprint/422728
ISSN: 0163-4453
PURE UUID: a3bfa6c7-bee9-4f25-893c-cc6229e87ab1
ORCID for Shengjie Lai: ORCID iD orcid.org/0000-0001-9781-8148

Catalogue record

Date deposited: 01 Aug 2018 16:30
Last modified: 22 May 2019 00:22

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×