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Trans- and inter-generational epigenetic inheritance in allergic diseases

Trans- and inter-generational epigenetic inheritance in allergic diseases
Trans- and inter-generational epigenetic inheritance in allergic diseases
It has become clear that early life (including in utero exposures), is a key window of vulnerability where environmental exposures can alter developmental trajectories and initiate allergic disease development. However, recent evidence suggests that there may be additional windows of vulnerability to environmental exposures in the parental generation before conception, or even in previous generations. There is evidence suggesting that information of prior exposures can be transferred across generations, and experimental animal models suggest that such transmission may be conveyed through epigenetic mechanisms. While the molecular mechanisms of inter- and trans-generation epigenetic transmission have yet to be determined, the realisation that environment before conception may alter risks of allergic diseases, has profound implications for the development of public health interventions to prevent disease. Future research in both experimental models and in multigenerational human cohorts is needed to better understand the role of inter- and trans-generational effects in asthma and allergic disease. This will provide the knowledge basis for a new approach to efficient intervention strategies aimed at reducing the major public health challenge of these conditions.
0091-6749
765-772
Mørkve Knudsen, Toril
3fd5cb7b-1f8c-4714-910a-18a82b5b2203
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Jiang, Yu
4fa0a27b-8c06-4988-832a-8f5fb3a3f1ec
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Svanes, Cecilie
4a547f80-e3d3-47b4-ae0a-2741ad93c629
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Mørkve Knudsen, Toril
3fd5cb7b-1f8c-4714-910a-18a82b5b2203
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Jiang, Yu
4fa0a27b-8c06-4988-832a-8f5fb3a3f1ec
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Svanes, Cecilie
4a547f80-e3d3-47b4-ae0a-2741ad93c629
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Mørkve Knudsen, Toril, Rezwan, Faisal I., Jiang, Yu, Karmaus, Wilfried, Svanes, Cecilie and Holloway, John W. (2018) Trans- and inter-generational epigenetic inheritance in allergic diseases. Journal of Allergy and Clinical Immunology, 142 (3), 765-772. (doi:10.1016/j.jaci.2018.07.007).

Record type: Article

Abstract

It has become clear that early life (including in utero exposures), is a key window of vulnerability where environmental exposures can alter developmental trajectories and initiate allergic disease development. However, recent evidence suggests that there may be additional windows of vulnerability to environmental exposures in the parental generation before conception, or even in previous generations. There is evidence suggesting that information of prior exposures can be transferred across generations, and experimental animal models suggest that such transmission may be conveyed through epigenetic mechanisms. While the molecular mechanisms of inter- and trans-generation epigenetic transmission have yet to be determined, the realisation that environment before conception may alter risks of allergic diseases, has profound implications for the development of public health interventions to prevent disease. Future research in both experimental models and in multigenerational human cohorts is needed to better understand the role of inter- and trans-generational effects in asthma and allergic disease. This will provide the knowledge basis for a new approach to efficient intervention strategies aimed at reducing the major public health challenge of these conditions.

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Revised_Rostrum_version_3.0_final_clean - Accepted Manuscript
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Figs. A & B: rostrum with woman - Accepted Manuscript
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More information

Accepted/In Press date: 17 July 2018
e-pub ahead of print date: 21 July 2018
Published date: 1 September 2018

Identifiers

Local EPrints ID: 422792
URI: http://eprints.soton.ac.uk/id/eprint/422792
ISSN: 0091-6749
PURE UUID: 55eb3c45-2fb9-4449-a414-5ea35bc17de5
ORCID for Faisal I. Rezwan: ORCID iD orcid.org/0000-0001-9921-222X
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 06 Aug 2018 16:30
Last modified: 18 Feb 2021 16:49

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Contributors

Author: Toril Mørkve Knudsen
Author: Faisal I. Rezwan ORCID iD
Author: Yu Jiang
Author: Wilfried Karmaus
Author: Cecilie Svanes

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