Early-life nutrition, epigenetics and prevention of obesity
Early-life nutrition, epigenetics and prevention of obesity
Rates of childhood obesity and associated noncommunicable diseases (NCDs) are increasing at alarming rates. Such NCDs now account for 60% of deaths globally. There is an urgent need to identify the risk factors for obesity and the underlying mechanisms, with a view to preventing obesity. There is now substantial observational and experimental data suggesting that early nutritional experiences change epigenetic processes to alter phenotype and influence the later risk of obesity and other NCDs. The alterations of phenotype may confer a Darwinian fitness advantage. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. The epigenetic changes induced during development function at the level of individual CpG dinucleotides in gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later NCDs and enable early intervention strategies to reduce the risk of later obesity
427-456
El-Heis, Sarah
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Lillycrop, Karen
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Burdge, Graham
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Gluckman, Peter D.
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Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
2018
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
El-Heis, Sarah, Lillycrop, Karen, Burdge, Graham, Gluckman, Peter D., Hanson, Mark and Godfrey, Keith
(2018)
Early-life nutrition, epigenetics and prevention of obesity.
In,
Tollefsbol, Trygve O.
(ed.)
Epigenetics in Human Disease.
2nd ed.
Elsevier, .
(doi:10.1016/B978-0-12-812215-0.00015-7).
Record type:
Book Section
Abstract
Rates of childhood obesity and associated noncommunicable diseases (NCDs) are increasing at alarming rates. Such NCDs now account for 60% of deaths globally. There is an urgent need to identify the risk factors for obesity and the underlying mechanisms, with a view to preventing obesity. There is now substantial observational and experimental data suggesting that early nutritional experiences change epigenetic processes to alter phenotype and influence the later risk of obesity and other NCDs. The alterations of phenotype may confer a Darwinian fitness advantage. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. The epigenetic changes induced during development function at the level of individual CpG dinucleotides in gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later NCDs and enable early intervention strategies to reduce the risk of later obesity
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Published date: 2018
Identifiers
Local EPrints ID: 422889
URI: http://eprints.soton.ac.uk/id/eprint/422889
PURE UUID: 68b8d273-f645-4a2f-83ba-03045cbb7e4b
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Date deposited: 07 Aug 2018 16:31
Last modified: 16 Mar 2024 04:21
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Contributors
Author:
Sarah El-Heis
Author:
Peter D. Gluckman
Editor:
Trygve O. Tollefsbol
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