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Early-life nutrition, epigenetics and prevention of obesity

Early-life nutrition, epigenetics and prevention of obesity
Early-life nutrition, epigenetics and prevention of obesity
Rates of childhood obesity and associated noncommunicable diseases (NCDs) are increasing at alarming rates. Such NCDs now account for 60% of deaths globally. There is an urgent need to identify the risk factors for obesity and the underlying mechanisms, with a view to preventing obesity. There is now substantial observational and experimental data suggesting that early nutritional experiences change epigenetic processes to alter phenotype and influence the later risk of obesity and other NCDs. The alterations of phenotype may confer a Darwinian fitness advantage. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. The epigenetic changes induced during development function at the level of individual CpG dinucleotides in gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later NCDs and enable early intervention strategies to reduce the risk of later obesity
427-456
Elsevier
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Tollefsbol, Trygve O.
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Tollefsbol, Trygve O.

El-Heis, Sarah, Lillycrop, Karen, Burdge, Graham, Gluckman, Peter D., Hanson, Mark and Godfrey, Keith (2018) Early-life nutrition, epigenetics and prevention of obesity. In, Tollefsbol, Trygve O. (ed.) Epigenetics in Human Disease. 2nd ed. Elsevier, pp. 427-456. (doi:10.1016/B978-0-12-812215-0.00015-7).

Record type: Book Section

Abstract

Rates of childhood obesity and associated noncommunicable diseases (NCDs) are increasing at alarming rates. Such NCDs now account for 60% of deaths globally. There is an urgent need to identify the risk factors for obesity and the underlying mechanisms, with a view to preventing obesity. There is now substantial observational and experimental data suggesting that early nutritional experiences change epigenetic processes to alter phenotype and influence the later risk of obesity and other NCDs. The alterations of phenotype may confer a Darwinian fitness advantage. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. The epigenetic changes induced during development function at the level of individual CpG dinucleotides in gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later NCDs and enable early intervention strategies to reduce the risk of later obesity

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Published date: 2018

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Local EPrints ID: 422889
URI: http://eprints.soton.ac.uk/id/eprint/422889
PURE UUID: 68b8d273-f645-4a2f-83ba-03045cbb7e4b
ORCID for Karen Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for Graham Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 07 Aug 2018 16:31
Last modified: 10 Nov 2021 03:01

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Contributors

Author: Sarah El-Heis
Author: Karen Lillycrop ORCID iD
Author: Graham Burdge ORCID iD
Author: Peter D. Gluckman
Author: Mark Hanson ORCID iD
Author: Keith Godfrey ORCID iD
Editor: Trygve O. Tollefsbol

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