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Relationships between maternal obesity and maternal and neonatal iron status

Relationships between maternal obesity and maternal and neonatal iron status
Relationships between maternal obesity and maternal and neonatal iron status
Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C- reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs. 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs. 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.
Flynn, Angela C.
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Begum, Shahina
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White, Sara L.
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Dalrymple, Kathryn
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Gill, Carolyn
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Alwan, Nisreen A.
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Kiely, Mairead
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Latunde-Dada, Gladys
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Bell, Ruth
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Briley, Annette L.
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Nelson, Scott M.
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Oteng-Ntim, Eugene
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Sandall, Jane
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Sanders, Thomas A.
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Whitworth, Melissa
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Murray, Dierdre M.
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Kenny, Louise C.
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Poston, Lucilla
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Flynn, Angela C.
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Begum, Shahina
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White, Sara L.
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Dalrymple, Kathryn
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Gill, Carolyn
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Alwan, Nisreen A.
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Kiely, Mairead
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Latunde-Dada, Gladys
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Bell, Ruth
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Briley, Annette L.
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Nelson, Scott M.
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Oteng-Ntim, Eugene
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Sandall, Jane
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Sanders, Thomas A.
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Whitworth, Melissa
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Murray, Dierdre M.
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Kenny, Louise C.
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Poston, Lucilla
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Flynn, Angela C., Begum, Shahina, White, Sara L., Dalrymple, Kathryn, Gill, Carolyn, Alwan, Nisreen A., Kiely, Mairead, Latunde-Dada, Gladys, Bell, Ruth, Briley, Annette L., Nelson, Scott M., Oteng-Ntim, Eugene, Sandall, Jane, Sanders, Thomas A., Whitworth, Melissa, Murray, Dierdre M., Kenny, Louise C. and Poston, Lucilla (2018) Relationships between maternal obesity and maternal and neonatal iron status. Nutrients, 10 (8), [1000]. (doi:10.3390/nu10081000).

Record type: Article

Abstract

Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C- reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs. 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs. 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.

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Accepted/In Press date: 24 July 2018
e-pub ahead of print date: 30 July 2018
Published date: August 2018

Identifiers

Local EPrints ID: 422909
URI: http://eprints.soton.ac.uk/id/eprint/422909
PURE UUID: cf6e6ce7-835c-4c9f-8771-a92b8f090e6c
ORCID for Nisreen A. Alwan: ORCID iD orcid.org/0000-0002-4134-8463

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Date deposited: 07 Aug 2018 16:31
Last modified: 27 Jan 2020 13:48

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Contributors

Author: Angela C. Flynn
Author: Shahina Begum
Author: Sara L. White
Author: Kathryn Dalrymple
Author: Carolyn Gill
Author: Mairead Kiely
Author: Gladys Latunde-Dada
Author: Ruth Bell
Author: Annette L. Briley
Author: Scott M. Nelson
Author: Eugene Oteng-Ntim
Author: Jane Sandall
Author: Thomas A. Sanders
Author: Melissa Whitworth
Author: Dierdre M. Murray
Author: Louise C. Kenny
Author: Lucilla Poston

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