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Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and Cobalt-porphyrin DNA conjugates

Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and Cobalt-porphyrin DNA conjugates
Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and Cobalt-porphyrin DNA conjugates
We describe an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin functionalised ssDNA probes. The sensitivity at the attomolar concentration level arises from an increased density of redox labels on the electrode surface compared to sensors without NP modification. The electrode detects as few as 23 DNA molecules, approaching single molecule detection.
1359-7345
11108-11111
Kaur, Balwinder
7080c8b4-6825-4180-874b-3221db9a124a
Malecka, Kamila
2b1d9c1a-03fc-4172-b0a0-87f0342d8635
Cristaldi, Domenico, Andrea
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Chay, Clarissa S.
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Mames, Iwona
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Radecka, Hanna
e103c3ea-c929-4858-8eee-aa1723a58cb2
Radecki, Jerzy
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Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Kaur, Balwinder
7080c8b4-6825-4180-874b-3221db9a124a
Malecka, Kamila
2b1d9c1a-03fc-4172-b0a0-87f0342d8635
Cristaldi, Domenico, Andrea
6da2333e-3305-4a8b-996f-e5a844c69cdc
Chay, Clarissa S.
0b134968-23f9-4c88-9fb8-226703b3ec09
Mames, Iwona
c7177d38-bda3-44d2-9140-9cfb9624ca49
Radecka, Hanna
e103c3ea-c929-4858-8eee-aa1723a58cb2
Radecki, Jerzy
febeba18-86c7-4213-8d06-2bbfe639b4b3
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d

Kaur, Balwinder, Malecka, Kamila, Cristaldi, Domenico, Andrea, Chay, Clarissa S., Mames, Iwona, Radecka, Hanna, Radecki, Jerzy and Stulz, Eugen (2018) Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and Cobalt-porphyrin DNA conjugates. Chemical Communications, 54 (79), 11108-11111. (doi:10.1039/C8CC05362F).

Record type: Article

Abstract

We describe an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin functionalised ssDNA probes. The sensitivity at the attomolar concentration level arises from an increased density of redox labels on the electrode surface compared to sensors without NP modification. The electrode detects as few as 23 DNA molecules, approaching single molecule detection.

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c8cc05362f - Accepted Manuscript
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Accepted/In Press date: 3 August 2018
e-pub ahead of print date: 6 August 2018
Published date: 6 August 2018
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Identifiers

Local EPrints ID: 423011
URI: http://eprints.soton.ac.uk/id/eprint/423011
DOI: doi:10.1039/C8CC05362F
ISSN: 1359-7345
PURE UUID: 67b1e679-8ab9-4b2f-bd46-093064f2150f
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 09 Aug 2018 16:30
Last modified: 16 Mar 2024 06:58

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Contributors

Author: Balwinder Kaur
Author: Kamila Malecka
Author: Domenico, Andrea Cristaldi
Author: Clarissa S. Chay
Author: Iwona Mames
Author: Hanna Radecka
Author: Jerzy Radecki
Author: Eugen Stulz ORCID iD

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