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Associative plasticity in supplementary motor area - motor cortex pathways in Tourette syndrome

Associative plasticity in supplementary motor area - motor cortex pathways in Tourette syndrome
Associative plasticity in supplementary motor area - motor cortex pathways in Tourette syndrome
The important role of the supplementary motor area (SMA) in the generation of tics and urges in Gilles de la Tourette syndrome (GTS) is underscored by an increased SMA-motor cortex (M1) connectivity. However, whether plasticity is also altered in SMA-M1 pathways is unclear. We explored whether SMA-M1 plasticity is altered in patients with Tourette syndrome. 15 patients with GTS (mean age of 33.4 years, SD = 9.9) and 19 age and sex matched healthy controls were investigated with a paired association stimulation (PAS) protocol using three transcranial magnetic stimulation (TMS) coils stimulating both M1 and the SMA. Standard clinical measures for GTS symptoms were collected. There was a significant PAS effect showing that MEP amplitudes measured in blocks during and after PAS were significantly higher compared to those in the first block. However, the degree of PAS was not differentially modulated between patients and controls as shown by a Bayesian data analysis. PAS effects in GTS correlated positively with the YGTSS motor tic severity. Plasticity previously reported to be altered in sensorimotor pathways in GTS is normal in SMA-M1 projections suggesting that the dysfunction of the SMA in GTS is not primarily related to altered plasticity in SMA-M1 connections.
2045-2322
1-8
Tübing, Jennifer
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Gigla, Bettina
e3feaa48-02f7-4476-8fd8-d9088b36d178
Brandt, Valerie
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Verrel, Julius
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Weissbach, Anne
d8b90a8c-05eb-47ac-9d69-0f8e06b55c7c
Beste, Christian
a8212bb8-92be-4008-86aa-1288d4668665
Münchau, Alexander
3b2a49fb-9d74-4958-8d91-5224e6ec3d38
Bäumer, Tobias
e384474b-39b8-4814-82c7-f51f214bc323
Tübing, Jennifer
f8634107-0558-4d50-b913-cbb7565f4d99
Gigla, Bettina
e3feaa48-02f7-4476-8fd8-d9088b36d178
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Verrel, Julius
784382a5-ebb1-47d5-835e-252a08741152
Weissbach, Anne
d8b90a8c-05eb-47ac-9d69-0f8e06b55c7c
Beste, Christian
a8212bb8-92be-4008-86aa-1288d4668665
Münchau, Alexander
3b2a49fb-9d74-4958-8d91-5224e6ec3d38
Bäumer, Tobias
e384474b-39b8-4814-82c7-f51f214bc323

Tübing, Jennifer, Gigla, Bettina, Brandt, Valerie, Verrel, Julius, Weissbach, Anne, Beste, Christian, Münchau, Alexander and Bäumer, Tobias (2018) Associative plasticity in supplementary motor area - motor cortex pathways in Tourette syndrome. Scientific Reports, 8, 1-8. (doi:10.1038/s41598-018-30504-8).

Record type: Article

Abstract

The important role of the supplementary motor area (SMA) in the generation of tics and urges in Gilles de la Tourette syndrome (GTS) is underscored by an increased SMA-motor cortex (M1) connectivity. However, whether plasticity is also altered in SMA-M1 pathways is unclear. We explored whether SMA-M1 plasticity is altered in patients with Tourette syndrome. 15 patients with GTS (mean age of 33.4 years, SD = 9.9) and 19 age and sex matched healthy controls were investigated with a paired association stimulation (PAS) protocol using three transcranial magnetic stimulation (TMS) coils stimulating both M1 and the SMA. Standard clinical measures for GTS symptoms were collected. There was a significant PAS effect showing that MEP amplitudes measured in blocks during and after PAS were significantly higher compared to those in the first block. However, the degree of PAS was not differentially modulated between patients and controls as shown by a Bayesian data analysis. PAS effects in GTS correlated positively with the YGTSS motor tic severity. Plasticity previously reported to be altered in sensorimotor pathways in GTS is normal in SMA-M1 projections suggesting that the dysfunction of the SMA in GTS is not primarily related to altered plasticity in SMA-M1 connections.

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s41598-018-30504-8 - Version of Record
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Accepted/In Press date: 31 July 2018
e-pub ahead of print date: 10 August 2018

Identifiers

Local EPrints ID: 423053
URI: https://eprints.soton.ac.uk/id/eprint/423053
ISSN: 2045-2322
PURE UUID: 07cf8d49-5747-4791-9302-4e7d0350f672

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Date deposited: 13 Aug 2018 16:30
Last modified: 19 Jul 2019 17:04

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Contributors

Author: Jennifer Tübing
Author: Bettina Gigla
Author: Valerie Brandt
Author: Julius Verrel
Author: Anne Weissbach
Author: Christian Beste
Author: Alexander Münchau
Author: Tobias Bäumer

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