The University of Southampton
University of Southampton Institutional Repository

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae
Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae
The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK’s National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children <5 years of age. Significantly increased carriage post-PCV13 was observed and lineage-specific associations with Streptococcus pneumoniae were seen before but not after PCV13 introduction. NTHi were characterized into 11 discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. The increased carriage could not be linked to the expansion of a particular clone and different co-carriage dynamics were seen before PCV13 implementation when NTHi co-carried with vaccine serotype pneumococci. In summary, PCV13 introduction has been shown to have an indirect effect on NTHi epidemiology and there exists both negative and positive, distinct associations between pneumococci and NTHi. This should be considered when evaluating the impacts of pneumococcal vaccine design and policy.
2057-5858
Cleary, David
f4079c6d-d54b-4108-b346-b0069035bec0
Devine, Vanessa
ce4845c0-7013-4e4f-9f57-e1616cc96e98
Morris, Denise
5de4af5f-4112-4bf5-a8b5-6636661244e9
Osman, Karen
9df79583-5da6-480e-ad25-189e8a4d63f2
Gladstone, Rebecca
6a2011bf-2561-4956-9928-46e6b927ba6d
Bentley, Stephen D
438443a4-8033-4a5d-a5a5-538dbd4e8d60
Faust, Saul
f97df780-9f9b-418e-b349-7adf63e150c1
Clarke, Stuart
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Cleary, David
f4079c6d-d54b-4108-b346-b0069035bec0
Devine, Vanessa
ce4845c0-7013-4e4f-9f57-e1616cc96e98
Morris, Denise
5de4af5f-4112-4bf5-a8b5-6636661244e9
Osman, Karen
9df79583-5da6-480e-ad25-189e8a4d63f2
Gladstone, Rebecca
6a2011bf-2561-4956-9928-46e6b927ba6d
Bentley, Stephen D
438443a4-8033-4a5d-a5a5-538dbd4e8d60
Faust, Saul
f97df780-9f9b-418e-b349-7adf63e150c1
Clarke, Stuart
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17

Cleary, David, Devine, Vanessa, Morris, Denise, Osman, Karen, Gladstone, Rebecca, Bentley, Stephen D, Faust, Saul and Clarke, Stuart (2018) Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae. Microbial Genomics. (doi:10.1099/mgen.0.000209).

Record type: Article

Abstract

The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK’s National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children <5 years of age. Significantly increased carriage post-PCV13 was observed and lineage-specific associations with Streptococcus pneumoniae were seen before but not after PCV13 introduction. NTHi were characterized into 11 discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. The increased carriage could not be linked to the expansion of a particular clone and different co-carriage dynamics were seen before PCV13 implementation when NTHi co-carried with vaccine serotype pneumococci. In summary, PCV13 introduction has been shown to have an indirect effect on NTHi epidemiology and there exists both negative and positive, distinct associations between pneumococci and NTHi. This should be considered when evaluating the impacts of pneumococcal vaccine design and policy.

Text
mgen000209 - Version of Record
Available under License Creative Commons Attribution.
Download (3MB)
Text
MGEN-D-18-00048_R2
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 18 July 2018
e-pub ahead of print date: 6 August 2018
Published date: 1 September 2018

Identifiers

Local EPrints ID: 423110
URI: https://eprints.soton.ac.uk/id/eprint/423110
ISSN: 2057-5858
PURE UUID: ee7a15cf-b886-468d-b2b5-2d7aa0f8a167
ORCID for David Cleary: ORCID iD orcid.org/0000-0003-4533-0700
ORCID for Saul Faust: ORCID iD orcid.org/0000-0003-3410-7642
ORCID for Stuart Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 14 Aug 2018 16:30
Last modified: 03 Dec 2019 01:46

Export record

Altmetrics

Contributors

Author: David Cleary ORCID iD
Author: Vanessa Devine
Author: Denise Morris
Author: Karen Osman
Author: Rebecca Gladstone
Author: Stephen D Bentley
Author: Saul Faust ORCID iD
Author: Stuart Clarke ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×