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The spatial arrangements of stochastic Ca2+ signals triggered by IP3 release

The spatial arrangements of stochastic Ca2+ signals triggered by IP3 release
The spatial arrangements of stochastic Ca2+ signals triggered by IP3 release
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on various spatial and temporal scales. We introduce a stochastic reaction-diffusion model of randomly distributed IP3 receptors using a principled reduction of a detailed Markov chain description of individual channels. Our model reveals how the crucial characteristic of cell regulation such as inter-wave intervals (IWI) depends on the IP3 loads. Furthermore, by performing a correlation analysis of the [Ca2+] at the neighbouring clusters, we obtain the principal characteristics of the membrane which define the possibility of Ca2+ wave initiation and propagation.
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698

Braichenko, Svitlana, Bhaskar, Atul and Dasmahapatra, Srinandan (2018) The spatial arrangements of stochastic Ca2+ signals triggered by IP3 release. 3rd European Calcium Channel Conference 2018, Alpbach, Austria. 09 - 12 May 2018.

Record type: Conference or Workshop Item (Poster)

Abstract

Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on various spatial and temporal scales. We introduce a stochastic reaction-diffusion model of randomly distributed IP3 receptors using a principled reduction of a detailed Markov chain description of individual channels. Our model reveals how the crucial characteristic of cell regulation such as inter-wave intervals (IWI) depends on the IP3 loads. Furthermore, by performing a correlation analysis of the [Ca2+] at the neighbouring clusters, we obtain the principal characteristics of the membrane which define the possibility of Ca2+ wave initiation and propagation.

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More information

Published date: 9 May 2018
Venue - Dates: 3rd European Calcium Channel Conference 2018, Alpbach, Austria, 2018-05-09 - 2018-05-12

Identifiers

Local EPrints ID: 423214
URI: https://eprints.soton.ac.uk/id/eprint/423214
PURE UUID: 1f879a43-d4e9-4aef-bb97-58e1a2e060a9

Catalogue record

Date deposited: 19 Sep 2018 16:30
Last modified: 19 Sep 2018 16:30

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Contributors

Author: Svitlana Braichenko
Author: Atul Bhaskar
Author: Srinandan Dasmahapatra

University divisions

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