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Calcium release dynamics in clusters of IP3 channels

Calcium release dynamics in clusters of IP3 channels
Calcium release dynamics in clusters of IP3 channels
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction- diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium releases -- puffs, waves and spikes respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters.
79
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e

Braichenko, Svitlana, Dasmahapatra, Srinandan and Bhaskar, Atul (2017) Calcium release dynamics in clusters of IP3 channels. EMBO workshop, LabEx INFORM: Dynamics of Living Systems, Cargese, France. 25 - 29 Sep 2017. p. 79 .

Record type: Conference or Workshop Item (Poster)

Abstract

Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction- diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium releases -- puffs, waves and spikes respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters.

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More information

Published date: 25 September 2017
Venue - Dates: EMBO workshop, LabEx INFORM: Dynamics of Living Systems, Cargese, France, 2017-09-25 - 2017-09-29

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Local EPrints ID: 423217
URI: https://eprints.soton.ac.uk/id/eprint/423217
PURE UUID: e3bfe92b-c8ce-4c0f-9db2-d2083b131a43

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Date deposited: 19 Sep 2018 16:30
Last modified: 19 Sep 2018 16:30

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