Calcium release dynamics in clusters of IP3 channels

Braichenko, Svitlana, Dasmahapatra, Srinandan and Bhaskar, Atul (2017) Calcium release dynamics in clusters of IP3 channels. EMBO workshop, LabEx INFORM: Dynamics of Living Systems, , Cargese, France. 24 - 28 Sep 2017. p. 79 .

Abstract

Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction- diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium releases -- puffs, waves and spikes respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters.

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