Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels
Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves, and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction-diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium release – puffs, waves, and oscillations respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters. We connect the termination of large-scale Ca2+ release events to IP3 unbinding or stochasticity.
calcium signaling, clustering, diffusion
1-16
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
September 2018
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Braichenko, Svitlana, Bhaskar, Atul and Dasmahapatra, Srinandan
(2018)
Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels.
Physical Review E, 98 (3), , [032413].
(doi:10.1103/PhysRevE.98.032413).
Abstract
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves, and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction-diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium release – puffs, waves, and oscillations respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters. We connect the termination of large-scale Ca2+ release events to IP3 unbinding or stochasticity.
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Accepted/In Press date: 23 August 2018
e-pub ahead of print date: 21 September 2018
Published date: September 2018
Keywords:
calcium signaling, clustering, diffusion
Identifiers
Local EPrints ID: 423229
URI: http://eprints.soton.ac.uk/id/eprint/423229
ISSN: 1539-3755
PURE UUID: 7a7046f1-66d9-4a98-b38e-267df0758b1d
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Date deposited: 19 Sep 2018 16:30
Last modified: 16 Mar 2024 07:01
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Author:
Svitlana Braichenko
Author:
Srinandan Dasmahapatra
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