The University of Southampton
University of Southampton Institutional Repository

Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels

Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels
Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves, and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction-diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of indi- vidual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium release – puffs, waves, and oscillations respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters. We connect the termination of large-scale Ca2+ release events to IP3 unbinding or stochasticity.
calcium signaling, clustering, diffusion
1539-3755
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Braichenko, Svitlana
52f8c64d-f16c-4c4f-9939-686cbdffedd4
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698

Braichenko, Svitlana, Bhaskar, Atul and Dasmahapatra, Srinandan (2018) Phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels. Physical Review E, 98. (doi:10.1103/PhysRevE.98.032413).

Record type: Article

Abstract

Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves, and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction-diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of indi- vidual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium release – puffs, waves, and oscillations respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters. We connect the termination of large-scale Ca2+ release events to IP3 unbinding or stochasticity.

Text
Main Text - Accepted Manuscript
Download (2MB)
Text
Supporting Material
Restricted to Repository staff only until 24 August 2019.
Request a copy

More information

Accepted/In Press date: 23 August 2018
e-pub ahead of print date: 21 September 2018
Keywords: calcium signaling, clustering, diffusion

Identifiers

Local EPrints ID: 423229
URI: https://eprints.soton.ac.uk/id/eprint/423229
ISSN: 1539-3755
PURE UUID: 7a7046f1-66d9-4a98-b38e-267df0758b1d

Catalogue record

Date deposited: 19 Sep 2018 16:30
Last modified: 20 Jul 2019 04:07

Export record

Altmetrics

Contributors

Author: Svitlana Braichenko
Author: Atul Bhaskar

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×