Signaling through the primary cilium
Signaling through the primary cilium
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term "the cells's antenna" as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the "ciliopathies" resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.
Wheway, Gabrielle
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Nazlamova, Liliya
d5b0375e-c00e-4bac-911b-d354afcab1a0
Hancock, John T.
5d99a63b-3d3e-4d5a-9cc0-d380d286b3aa
8 February 2018
Wheway, Gabrielle
2e547e5d-b921-4243-a071-2208fd4cc090
Nazlamova, Liliya
d5b0375e-c00e-4bac-911b-d354afcab1a0
Hancock, John T.
5d99a63b-3d3e-4d5a-9cc0-d380d286b3aa
Wheway, Gabrielle, Nazlamova, Liliya and Hancock, John T.
(2018)
Signaling through the primary cilium.
Frontiers in Cell and Developmental Biology, 6 (8).
(doi:10.3389/fcell.2018.00008).
Abstract
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term "the cells's antenna" as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the "ciliopathies" resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.
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fcell-06-00008
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Accepted/In Press date: 23 January 2018
e-pub ahead of print date: 8 February 2018
Published date: 8 February 2018
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Local EPrints ID: 423508
URI: http://eprints.soton.ac.uk/id/eprint/423508
PURE UUID: 74c0eca8-2781-4ce0-9f9f-639692bb7aaf
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Date deposited: 25 Sep 2018 16:30
Last modified: 16 Mar 2024 04:38
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Author:
Liliya Nazlamova
Author:
John T. Hancock
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