The University of Southampton
University of Southampton Institutional Repository

Sex differences in risk-based decision making in adolescents with conduct disorder

Sex differences in risk-based decision making in adolescents with conduct disorder
Sex differences in risk-based decision making in adolescents with conduct disorder

Altered decision making processes and excessive risk-seeking behaviours are key features of conduct disorder (CD). Previous studies have provided compelling evidence of abnormally increased preference for risky options, higher sensitivity to rewards, as well as blunted responsiveness to aversive outcomes in adolescents with CD. However, most studies published to date have focused on males only; thus, it is not known whether females with CD show similar alterations in decision making. The current study investigated potential sex differences in decision making and risk-seeking behaviours in adolescents with CD. Forty-nine adolescents with CD (23 females) and 51 control subjects (27 females), aged 11-18 years, performed a computerised task assessing decision making under risk—the Risky Choice Task. Participants made a series of decisions between two gamble options that varied in terms of their expected values and probability of gains and losses. This enabled the participants’ risk preferences to be determined. Taking the sample as a whole, adolescents with CD exhibited increased risk-seeking behaviours compared to healthy controls. However, we found a trend towards a sex-by-group interaction, suggesting that these effects may vary by sex. Follow-up analyses showed that males with CD made significantly more risky choices than their typically developing counterparts, while females with CD did not differ from typically developing females in their risk-seeking behaviours. Our results provide preliminary evidence that sex may moderate the relationship between CD and alterations in risk attitudes and reward processing, indicating that there may be sex differences in the developmental pathways and neuropsychological deficits that lead to CD.

Antisocial behaviour, Conduct disorder, Decision making, Reward, Risk, Sex differences
1018-8827
1133-1142
Sidlauskaite, Justina
d23d77bb-7bae-4b01-99e2-8c63e5e7d0cf
González-Madruga, Karen
72c8192c-95dd-4c29-8cf5-4a95790b3661
Smaragdi, Areti
b090586a-a5c3-4ec0-b05e-167a5a0f4543
Riccelli, Roberta
17dc2394-bc7c-4480-9cdf-e21a7a503061
Puzzo, Ignazio
8d08d90f-23a2-4377-9c1f-984dade361b1
Batchelor, Molly
13a099f0-fdb6-4afc-a0ad-1b07bfe154f2
Cornwell, Harriet
f6cc3a18-5098-4518-9849-3edb8bd5a3e1
Clark, Luke
d0d03564-0462-4056-ab19-b511acc1321b
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Fairchild, Graeme
f99bc911-978e-48c2-9754-c6460666a95f
Sidlauskaite, Justina
d23d77bb-7bae-4b01-99e2-8c63e5e7d0cf
González-Madruga, Karen
72c8192c-95dd-4c29-8cf5-4a95790b3661
Smaragdi, Areti
b090586a-a5c3-4ec0-b05e-167a5a0f4543
Riccelli, Roberta
17dc2394-bc7c-4480-9cdf-e21a7a503061
Puzzo, Ignazio
8d08d90f-23a2-4377-9c1f-984dade361b1
Batchelor, Molly
13a099f0-fdb6-4afc-a0ad-1b07bfe154f2
Cornwell, Harriet
f6cc3a18-5098-4518-9849-3edb8bd5a3e1
Clark, Luke
d0d03564-0462-4056-ab19-b511acc1321b
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Fairchild, Graeme
f99bc911-978e-48c2-9754-c6460666a95f

Sidlauskaite, Justina, González-Madruga, Karen, Smaragdi, Areti, Riccelli, Roberta, Puzzo, Ignazio, Batchelor, Molly, Cornwell, Harriet, Clark, Luke, Sonuga-Barke, Edmund J.S. and Fairchild, Graeme (2018) Sex differences in risk-based decision making in adolescents with conduct disorder. European Child and Adolescent Psychiatry, 27 (9), 1133-1142. (doi:10.1007/s00787-017-1024-9).

Record type: Article

Abstract

Altered decision making processes and excessive risk-seeking behaviours are key features of conduct disorder (CD). Previous studies have provided compelling evidence of abnormally increased preference for risky options, higher sensitivity to rewards, as well as blunted responsiveness to aversive outcomes in adolescents with CD. However, most studies published to date have focused on males only; thus, it is not known whether females with CD show similar alterations in decision making. The current study investigated potential sex differences in decision making and risk-seeking behaviours in adolescents with CD. Forty-nine adolescents with CD (23 females) and 51 control subjects (27 females), aged 11-18 years, performed a computerised task assessing decision making under risk—the Risky Choice Task. Participants made a series of decisions between two gamble options that varied in terms of their expected values and probability of gains and losses. This enabled the participants’ risk preferences to be determined. Taking the sample as a whole, adolescents with CD exhibited increased risk-seeking behaviours compared to healthy controls. However, we found a trend towards a sex-by-group interaction, suggesting that these effects may vary by sex. Follow-up analyses showed that males with CD made significantly more risky choices than their typically developing counterparts, while females with CD did not differ from typically developing females in their risk-seeking behaviours. Our results provide preliminary evidence that sex may moderate the relationship between CD and alterations in risk attitudes and reward processing, indicating that there may be sex differences in the developmental pathways and neuropsychological deficits that lead to CD.

Text
Sidlauskaite2018_Article_SexDifferencesInRisk-basedDeci - Version of Record
Available under License Creative Commons Attribution.
Download (904kB)

More information

Accepted/In Press date: 29 June 2017
e-pub ahead of print date: 7 July 2017
Published date: 1 September 2018
Keywords: Antisocial behaviour, Conduct disorder, Decision making, Reward, Risk, Sex differences

Identifiers

Local EPrints ID: 423548
URI: http://eprints.soton.ac.uk/id/eprint/423548
ISSN: 1018-8827
PURE UUID: eca527a0-5082-467f-8cd0-8b7a9c5a9176
ORCID for Graeme Fairchild: ORCID iD orcid.org/0000-0001-7814-9938

Catalogue record

Date deposited: 26 Sep 2018 16:30
Last modified: 07 Oct 2020 00:35

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×