Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis
Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis
Much data support a role for central nervous system antigen-specific antibodies in the pathogenesis of multiple sclerosis (MS). The effects of inducing a decrease in (auto)antibody levels on MS or experimental autoimmune encephalomyelitis (EAE) through specific blockade of FcRn, however, remain unexplored. We recently developed engineered antibodies that lower endogenous IgG levels by competing for binding to FcRn. These Abdegs ("antibodies that enhance IgG degradation") can be used to directly assess the effect of decreased antibody levels in inflammatory diseases. In the current study, we show that Abdeg delivery ameliorates disease in an EAE model that is antibody dependent. Abdegs could therefore have promise as therapeutic agents for MS.
Autoantibody, EAE, Engineered antibodies, FcRn, Therapy
655-659
Challa, Dilip K.
433af413-17a0-4c55-b86f-21e4e5cedd6f
Bussmeyer, Uta
8ff8258f-2e62-421f-859a-cd11f75f0720
Khan, Tarique
507025ba-bbc4-496b-a52f-0956a3b58c32
Montoyo, Héctor P.
a5e38131-2c10-4922-b196-693e6effa1b3
Bansal, Pankaj
912367d9-bcdd-4a8c-a7dd-8ee4f9ed6691
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Sally Ward, E.
b31c0877-8abe-485f-b800-244a9d3cd6cc
September 2013
Challa, Dilip K.
433af413-17a0-4c55-b86f-21e4e5cedd6f
Bussmeyer, Uta
8ff8258f-2e62-421f-859a-cd11f75f0720
Khan, Tarique
507025ba-bbc4-496b-a52f-0956a3b58c32
Montoyo, Héctor P.
a5e38131-2c10-4922-b196-693e6effa1b3
Bansal, Pankaj
912367d9-bcdd-4a8c-a7dd-8ee4f9ed6691
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Sally Ward, E.
b31c0877-8abe-485f-b800-244a9d3cd6cc
Challa, Dilip K., Bussmeyer, Uta, Khan, Tarique, Montoyo, Héctor P., Bansal, Pankaj, Ober, Raimund J. and Sally Ward, E.
(2013)
Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis.
mAbs, 5 (5), .
(doi:10.4161/mabs.25439).
Abstract
Much data support a role for central nervous system antigen-specific antibodies in the pathogenesis of multiple sclerosis (MS). The effects of inducing a decrease in (auto)antibody levels on MS or experimental autoimmune encephalomyelitis (EAE) through specific blockade of FcRn, however, remain unexplored. We recently developed engineered antibodies that lower endogenous IgG levels by competing for binding to FcRn. These Abdegs ("antibodies that enhance IgG degradation") can be used to directly assess the effect of decreased antibody levels in inflammatory diseases. In the current study, we show that Abdeg delivery ameliorates disease in an EAE model that is antibody dependent. Abdegs could therefore have promise as therapeutic agents for MS.
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Accepted/In Press date: 17 June 2013
e-pub ahead of print date: 19 June 2013
Published date: September 2013
Keywords:
Autoantibody, EAE, Engineered antibodies, FcRn, Therapy
Identifiers
Local EPrints ID: 423648
URI: http://eprints.soton.ac.uk/id/eprint/423648
ISSN: 1942-0862
PURE UUID: 2a636e8d-5149-4aec-a0d0-9b8aa987d6a2
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Date deposited: 27 Sep 2018 16:30
Last modified: 18 Mar 2024 03:48
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Contributors
Author:
Dilip K. Challa
Author:
Uta Bussmeyer
Author:
Tarique Khan
Author:
Héctor P. Montoyo
Author:
Pankaj Bansal
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