Targeting FcRn for therapy: From live cell imaging to in vivo studies in mice
Targeting FcRn for therapy: From live cell imaging to in vivo studies in mice
The role of FcRn in regulating antibody levels and transport in the body is well documented. The use of fluorescence microscopy to investigate the subcellular trafficking behavior of FcRn and its IgG ligand has led to insight into the function of this receptor, including the identification of new intracellular pathways. The inhibition of FcRn using engineered antibodies that bind to this receptor with increased affinity through their Fc region can be exploited to treat antibody mediated autoimmunity. The efficacy of this approach in mouse models of arthritis and multiple sclerosis has been demonstrated. Finally, the cross-species difference between mouse and man for FcRn-IgG interactions needs to be considered when engineering antibodies for improved activities in FcRn-mediated functions.
Antibody engineering, Antibody pharmacokinetics, Autoimmunity, FcRn, Immunoglobulin G, Live-imaging microscopy
158-162
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Velmurugan, Ramraj
4f2d41cd-90eb-4f61-b5e0-df6308726d28
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
August 2014
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Velmurugan, Ramraj
4f2d41cd-90eb-4f61-b5e0-df6308726d28
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Ward, E. Sally, Velmurugan, Ramraj and Ober, Raimund J.
(2014)
Targeting FcRn for therapy: From live cell imaging to in vivo studies in mice.
Immunology Letters, 160 (2), .
(doi:10.1016/j.imlet.2014.02.008).
Abstract
The role of FcRn in regulating antibody levels and transport in the body is well documented. The use of fluorescence microscopy to investigate the subcellular trafficking behavior of FcRn and its IgG ligand has led to insight into the function of this receptor, including the identification of new intracellular pathways. The inhibition of FcRn using engineered antibodies that bind to this receptor with increased affinity through their Fc region can be exploited to treat antibody mediated autoimmunity. The efficacy of this approach in mouse models of arthritis and multiple sclerosis has been demonstrated. Finally, the cross-species difference between mouse and man for FcRn-IgG interactions needs to be considered when engineering antibodies for improved activities in FcRn-mediated functions.
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More information
Accepted/In Press date: 14 February 2014
e-pub ahead of print date: 23 February 2014
Published date: August 2014
Keywords:
Antibody engineering, Antibody pharmacokinetics, Autoimmunity, FcRn, Immunoglobulin G, Live-imaging microscopy
Identifiers
Local EPrints ID: 423655
URI: http://eprints.soton.ac.uk/id/eprint/423655
ISSN: 0165-2478
PURE UUID: 5c327708-9809-497a-8dd3-be81bd24df1d
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Date deposited: 27 Sep 2018 16:30
Last modified: 18 Mar 2024 03:48
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Author:
Ramraj Velmurugan
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