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Limit of the accuracy of parameter estimation for two molecules moving in close proximity

Limit of the accuracy of parameter estimation for two molecules moving in close proximity
Limit of the accuracy of parameter estimation for two molecules moving in close proximity

Biomolecular interactions are central to biological processes and typically take place at nanometer scale distances. They often involve molecular motion which is known to affect the accuracy of the parameter estimates. Therefore, in this paper, we consider a case of two closely spaced molecules with planar trajectory and present a general expression of the Fisher information matrix in terms of their trajectory from which the benchmark for the accuracy of the parameter estimates is obtained. Through simulations, we show its application in the case of two moving objects and another case where only one of the two objects is moving. It is shown that the deterioration of the limit of the accuracy is not only dependent on the proximity of their starting position but also on their speed and direction of movement. The effect of differing photon emission intensities on the limit of the accuracy of parameter estimation is also investigated.

441-444
IEEE
Lin, Zhiping
9b046adc-5fd0-4f26-a722-4e72598ecd9f
Wong, Yau
36160933-9ffd-441e-84f7-23ace7af822a
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Lin, Zhiping
9b046adc-5fd0-4f26-a722-4e72598ecd9f
Wong, Yau
36160933-9ffd-441e-84f7-23ace7af822a
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36

Lin, Zhiping, Wong, Yau and Ober, Raimund J. (2015) Limit of the accuracy of parameter estimation for two molecules moving in close proximity. In 2015 IEEE International Symposium on Circuits and Systems, ISCAS 2015. vol. 2015-July, IEEE. pp. 441-444 . (doi:10.1109/ISCAS.2015.7168665).

Record type: Conference or Workshop Item (Paper)

Abstract

Biomolecular interactions are central to biological processes and typically take place at nanometer scale distances. They often involve molecular motion which is known to affect the accuracy of the parameter estimates. Therefore, in this paper, we consider a case of two closely spaced molecules with planar trajectory and present a general expression of the Fisher information matrix in terms of their trajectory from which the benchmark for the accuracy of the parameter estimates is obtained. Through simulations, we show its application in the case of two moving objects and another case where only one of the two objects is moving. It is shown that the deterioration of the limit of the accuracy is not only dependent on the proximity of their starting position but also on their speed and direction of movement. The effect of differing photon emission intensities on the limit of the accuracy of parameter estimation is also investigated.

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More information

Published date: 27 July 2015
Venue - Dates: IEEE International Symposium on Circuits and Systems, ISCAS 2015, , Lisbon, Portugal, 2015-05-24 - 2015-05-27

Identifiers

Local EPrints ID: 423665
URI: http://eprints.soton.ac.uk/id/eprint/423665
PURE UUID: 409bfcc2-5c96-4c2d-b84e-edbe4daa8758
ORCID for Raimund J. Ober: ORCID iD orcid.org/0000-0002-1290-7430

Catalogue record

Date deposited: 27 Sep 2018 16:30
Last modified: 16 Mar 2024 04:37

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Contributors

Author: Zhiping Lin
Author: Yau Wong
Author: Raimund J. Ober ORCID iD

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